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Dysfunction of the NE leads to various human diseases, including premature ageing syndromes called progeria.

Unfortunately, there is no current cure for these diseases, and the available therapies mainly act by improving the symptoms of these patients. Our lab is interested in characterizing new mechanisms that regulate NE function to improve our fundamental knowledge and to suggest new ways of treating these diseases.

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Our work could also open up new perspectives into improving normal age-related pathologies. International students Continuing education Executive and professional education Courses in education. Nuclear envelope regulation and links with disease The nuclear envelope NE lies at the interface between the nucleus and the cytoskeleton.


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High resolution immunofluorescence images showing nuclear envelope staining green and nucleolar staining red and blue. Progeria cells right display characteristic nuclear envelope deformation compared to wildtype cells left.

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How does NAT10 regulate nuclear envelope function? We identified Remodelin by screening for new compounds that can improve phenotypes of cells from Hutchinson Gilford Progeria Syndrome. We showed that Remodelin acts by targeting a protein called NAT We are currently investigating the molecular mechanisms behind this rescue. Identification of new regulatory pathways in premature ageing syndromes In addition, we are working on identifying new candidates involved in NE control by carrying out complementary high throughput crispr-cas9 genetic and chemical screens.

Contact us Postal Address: Study at Cambridge Undergraduate Graduate International students Continuing education Executive and professional education Courses in education. But what is wrong with that - who doesn't like dolphins!? I love them, and think that this name is a great way to honour a water-baby. It also has the French slant to it and is like the flower, Delphinium see meaning below. I am in love with this name.

DELPHINE BEDEL

Delphinium is commonly known as Larkspur, and is the allocated birth flower of July in the UK at least. Named my daughter this name a few months back. And of course, the animal, Dolphin. Delphine is the French form of Delphina and the feminine form of the Roman name Delphinus.

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Delphinus means "of Delphi" in Latin. Delphi is a Greek city, which in ancient times was the site of the famous Delphic oracle. The Greek word for dolphin delphis is also the inspirational name of the flowering plant, commonly known as Larkspur, scientifically known as Delphinium, so-named because of the flower heads shaped like a dolphins.

Delphine Gillet

So the name Delphine actually comes from the flower, Delphinium, which is named after our dolphin friends of the sea. Search for a Name. Origin of the name Delphine: What are her siblings named? Contribute your knowledge to the name Delphine Report inappropriate content.