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Refresh and try again. Quotes by Kieran O'Hagan. Emotional abuse impedes emotional development. Each employee is empowered to take ownership of their development, and encouraged to take Sales Associate salaries in Reno, NV Learn more about working at Vans Vans questions about work, benefits, interviews and hiring process: What should you wear to an interview? What questions did they ask during your interview?
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Books by Kieran O'Hagan (Author of The Verdi Solution)
Reno, Nevada - Whittier Trust Company. Proactive and organized, the candidate effectively manages multiple concurrent projects while maintaining exceptional attention to detail and meeting deadlines Ten members of the research group GIBI are participating with ten oral and two posters contributions. Maria Vallet is participating as coordinator of biomaterials and healthcare area, which comprises 6 different symposiums and as member of scientific committee.
Baeza are participating as organiser and chair in different symposiums. Important Biomaterials Science Controversies.
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International Conference on Nanomedicine and nanobiotechnology. Principles for engineering nanoparticles loaded with drugs and molecular machines". Madrid, April, , Journal of Non-Crystalline Solids 90— Acta Biomaterialia 49 — The application of nanotechnology to medicine constitutes a major field of research nowadays. In particular, the use of mesoporous silica and carbon nanoparticles has attracted the attention of numerous researchers due to their unique properties, especially when applied to cancer treatment. Many strategies based on stimuli-responsive nanocarriers have been developed to control the drug release and avoid premature release.
Here, we focus on the use of the subtle changes of pH between healthy and diseased areas along the body to trigger the release of the cargo. In this review, different approximations of pH-responsive systems are considered: Nanocarriers have emerged as a powerful alternative for cancer therapy. Such is the importance of these gene-keeping biomacromolecules that even nanomaterials have succumbed to the claimed benefits of DNA and RNA. Osteoporosis is by far the most frequent metabolic disease affecting bone. Current clinical therapeutic treatments are not able to offer long-term solutions.
Most of the clinically used antiosteoporotic drugs are administered systemically, which might lead to side effects in non-skeletal tissues. Therefore, to solve these disadvantages, researchers have turned to nanotechnologies and nanomaterials to create innovative and alternative treatments. One of the innovative approaches to enhance osteoporosis therapy and prevent potential adverse effects is the development of bonetargeting drug delivery technologies.
It minimizes the systemic toxicity and also improves the pharmacokinetic profile and therapeutic efficacy of chemical drugs. This paper reviews the current available bone targeting drug delivery systems, focusing on nanoparticles, proposed for osteoporosis treatment. Bone targeting delivery systems is still in its infancy, thus, challenges are ahead of us, including the stability and the toxicity issues.
Newly developed biomaterials and technologies with potential for safer and more effective drug delivery, require multidisciplinary collaboration between scientists from many different areas, such as chemistry, biology, engineering, medicine, etc, in order to facilitate their clinical applications. The incidence and the mortality of cancer increase with age. This article explores the possibility of decreasing cancerrelated mortality in the aged with secondary prevention of cancer deaths that entails early diagnosis of cancer through the screening of asymptomatic older individuals.
We establish that screening of asymptomatic individuals should be based on physiologic rather than chronologic age that may be estimated from a comprehensive geriatric assessment and possibly with the utilization of biologic markers of aging. It is reasonable to offer some form of screening for lung and colorectal cancer to individuals with a life expectancy of at least five years and screening for breast and prostate cancer to women and men respectively with a life expectancy of at least ten years. The ideal number of screening sessions and the ideal interval between screening sessions is unestablished.
The aging of the population, the diversity of the older population, the development of new and more sensitive screening interventions, the discovery of new biologic markers of cancer and age represent the main challenges in studying the value of cancer screening in the aged. Probably the most reliable information may be obtained from rapid-learning databases in which information related to each person"s physiologic age is included.
In addition, this capability is maintained inside the cells used as carriers. Acta Biomaterialia 55 — The selective transportation of therapeutic agents to tumoral cells is usually achieved by their conjugation with targeting moieties able to recognize these cells. Unfortunately, simple and static targeting systems usually show a lack in selectivity. Herein, a double sequential encrypted targeting system is proposed as a stimuli-responsive targeting analogue for selectivity enhancement.
The system is able to recognize diseased bone tissue in the first place, and once there, a hidden secondary targeting group is activated by the presence of an enzyme overproduced in the malignant tissue cathepsin K , thereby triggering the recognition of diseased cells. Transporting the cell targeting agent in a hidden conformation that contains a high selective tissular primary targeting, could avoid not only its binding to similar cell receptors but also the apparition of the binding-site barrier effect, which can enhance the penetration of the therapeutic agent within the affected zone.
This strategy could be applied not only to conjugate drugs but also to drug-loaded nanocarriers to improve the efficiency for bone cancer treatments. The surface functionalization with organic groups did not damage the mesoporous network and their structural and textural properties were also preserved despite the high solubility of MBG atrices.
The incorporation of Lys confers a zwitterionic nature to these MBG materials due to the presence of adjacent amine and carboxylic groups in the external surface. At physiologic pH, this coexistence of basic amine and carboxilic acid groups from anchored Lys provided zero surface charge named zwitterionic effect. This behaviour could give rise to potential applications of antibacterial adhesion.
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It was demonstrated that the efficient interaction of these zwitterionic pairs onto the MBG surfaces reduced bacterial adhesion up to These findings suggested that the proposed surface functionalization strategy provided MBG materials with notable antibacterial adhesion properties, hence making these materials promising candidates for local bone infection therapy.
Acta Biomaterialia 57 — However, migration of RAW This paper proposes a facile strategy for the zwitterionization of bioceramics that is based on the direct incorporation of L-lysine amino acid via the "-amino group onto mesoporous MCM materials.
Both elemental and thermogravimetric analyses showed that the amount of grafted lysine was 8 wt. Biofilm studies onto surfaces showed that lysine functionalization elicited a reduction of the area covered by S. This research shows a simple and effective approach to chemically modify bioceramics using single amino acids that provides zwitterionic functionality, which is useful to develop new biomaterials that are able to resist bacterial adhesion. Handbook of Sol-Gel Science and Technology.
Materials for tissue engineeringAutores: Ordered Mesoporous Silica Materials. Bioactive glasses, 2nd Edition. Use of bioactive glasses as bone substitutes in orthopedics and traumatologyAutores: Silica mesoporous nanomaterials have been proved to have meaningful application in biotechnology and biomedicine. Particularly, mesoporous bioactive glasses are recently gaining importance thanks to their bone regenerative properties. Moreover, the mesoporous nature of these materials makes them suitable for drug delivery applications, opening new lines in the field of bone therapies.
In this work, we have developed innovative nanodevices based on the implementation of adenosine triphosphate ATP and e-poly-llysine molecular gates using a mesoporous bioglass as an inorganic support. The systems have been previously proved to work properly with a fluorescence probe and subsequently with an antibiotic levofloxacin and an antitumoral drug doxorubicin. The bioactivity of the preparedmaterials has also been tested, giving promising results. Finally, in vitro cell culture studies have been carried out; demonstrating that this gated devices can provide useful approaches for bone cancer and bone infection treatments.
Acta Biomaterialia 50 — This manuscript reports an effective new alternative for the management of bone infection by the development of an antibiotic nanocarrier able to penetrate bacterial biofilm, thus enhancing antimicrobial effectiveness. This amine functionalization provides MSNs of positive charges, which improves the affinity towards the negatively charged bacteria wall and biofilm. The efficacy of the nanoantibiotic against a S. These findings open up promising expectations in the field of bone infection treatment.
A novel multifunction al nanodevice based in doxorubicin DOX -loaded mesoporous silica nanoparticles MSNs as nanoplatforms for the assembly of different building blocks has been developed for bone cancer treatment. These building blocks consists of: This multifunctional nanosystem exhibits a noticeable higher internalization degree into human osteosarcoma cells HOS , overexpressing SA, compared to healthy preosteoblast cells MC3T3-E1.