The Scripps Research team found that the cells of high-risk individuals showed an unusually broad set of abnormalities, with the risk cells affecting more than genes—nearly 10 percent of the total human gene catalog.
Computer-based examinations of these genes suggested that the muscle cells might be deficient in key functions related to disease. Next, the Baldwin group asked whether these or so genes might help demystify the influence of around other genes recently linked to coronary artery disease risk. Unexpectedly, the high-risk cells showed changes in more than a third of these 38 , suggesting that the 9p Delving more deeply, the group identified a potential key master regulator ANRIL , which itself is a member of an enigmatic class of genes that do not make proteins—instead generating genetic molecules called long non-coding RNAs.
Engler and Fyodor Urnov. For more information, contact press scripps.
Scientists cut main heart disease risk locus out of DNA by genome editing
Atherosclerosis , also known as hardening of the arteries, occurs when plaque builds up on the walls of your arteries and eventually blocks blood flow. Plaque is made of cholesterol, fat, and calcium. Coronary artery disease indicates that the plaque buildup in your arteries has caused the arteries to narrow and harden.
Blood clots can further block the arteries. Coronary artery disease develops over time. You can have it but not be aware of any symptoms. Other times, it may cause chest pain or the sensation of heaviness in the chest. A heart attack occurs when not enough blood reaches your heart. This can happen due to artery blockage. Heart attacks damage the heart muscle and are medical emergencies.
Women often experience heart attacks a little differently, with pressure or aching in their back and chest. Sometimes called congestive heart failure, heart failure occurs when the heart muscle is weakened or damaged.
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It can no longer pump the volume of blood needed through the body. Early symptoms of heart failure include fatigue, swelling in your ankles, and increased need to urinate at night. More severe symptoms include rapid breathing, chest pain, and fainting. For more on heart failure and how to recognize it, read about congestive heart failure.
Strokes often occur when a blood clot blocks an artery in the brain and reduces the blood supply. They also can happen when a blood vessel in the brain breaks open. Both events keep blood and oxygen from reaching the brain.
Cardiovascular disease
As a result, parts of the brain are likely to be damaged. An abdominal aortic aneurism is a bulge in a weakened part of the aorta. The aorta is the largest blood vessel in your body.
It carries blood from your heart to your abdomen, legs, and pelvis. When it becomes larger, you may experience pain in the abdomen or back. Large and rapidly growing abdominal aortic aneurisms are at greatest risk of rupturing.
These require immediate attention. Peripheral artery disease PAD is atherosclerosis that occurs in the extremities, usually in your legs. If you want to find out more, speak to your cardiologist.
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Living with an inherited cardiac condition can be distressing for both those with the condition and their families. There is support available through psychological help and genetic counselling. Genetic services in Scotland are managed by specialist hospital doctors in four regional centres:. It links with patient organisations and charities. Those in the network include:.
Inherited heart conditions - Illnesses & conditions | NHS inform
FANS also has a Patient Forum made up of people with inherited cardiac conditions and relatives of those affected. Home Illnesses and conditions Heart and blood vessels Conditions Inherited heart conditions. Treatments Different conditions require different treatments or interventions, which include: Support Living with an inherited cardiac condition can be distressing for both those with the condition and their families. Genetic services in Scotland are managed by specialist hospital doctors in four regional centres: Aberdeen - phone Dundee - phone Edinburgh - phone Glasgow - phone These regional services have access to: