By interference from retrograde labelling in control animals, sympathetic neurones supplying the mesenteric arteries were present in all these ganglia, as well as in the thoracic and lumbar paravertebral sympathetic chains. The results suggest that two functionally distinct populations of sympathetic neurones, which overlap considerably in their distributions, are differentially sensitive to the immunological postnatal removal of NGF.
Career Summary Biography Investigations are being made on cellular rhythms including those in lymphatics, blood vessels, gastrointestinal tract, heart and specific mood-associated brain nuclei.
Research Expertise Lymphatic and gastric pacemaking: Pacemaking in the lymphatic and gastric systems are the basis for our discovery of store pacemaking and calcium phase waves. We are now unravelling the finer details of these mechanisms. Importantly, as for all good research, there can often be unexpected yet important serendipitous outcomes.
One in case is that this work has led to development of a first aid treatment against bites from venomous animals whose venoms transit the lymphatic system and we have a patent application on this finding under review. Traditionally, this has been considered to operate through a clock in the cell surface membrane of pacemaker cells. However, recent evidence from our pilot and modelling studies and from the work of others indicates a significant role of calcium stores. This introduces the possibility that the heart pacemaker model is only part of the story and that pacemaking involves an intracellular clock i.
We are investigating this hypothesis, which if upheld will change the text book model for heart pacemaking and help change present understanding of specific heart disorders and their treatment. Brain rhythms function in most areas of the brain and while fundamental to life and our psyche remain poorly understood.
Neil Van Helden
We are testing the hypothesis that specific rhythms in the Locus Coeruleus, a brain stem nucleus known to be associated with mood states, are generated by store pacemaking. Evidence that the rhythms are generated by store pacemaking could provide a new framework for interpreting drug action in the treatment of mood disorders such as Bipolar Disorder.
Astonishingly, there is still no clear understanding of the pacemaker mechanism that initiates and times uterine contractions. Pilot studies we have undertaken suggest this to be mediated by store pacemaking. Proof for this hypothesis would herald a mechanistic description for uterine contractions and may provide new insight into associated dysfunctions such as premature birth. Keywords Cellular physiologist gastrointestinal physiology heart pacemaking neuroscience smooth muscle.
Publications Journal article Conference 64 For publications that are currently unpublished or in-press, details are shown in italics. NSW Ministry of Health. Vascular adaptation of the newborn: University of Newcastle - Faculty of Health and Medicine. Hunter Medical Research Institute. How do they work? British Physiological Society Meeting: University of New South Wales. Ratiometric Ion Imaging System. Mechanisms of action of omega-3 fatty acids in reduction of hypertension.
British Physiological and Pharmacological Society Meeting. Rhythmicity, synchronicity and spasm in smooth muscle. Rhythmicity, Synchronicity and Spasm in Smooth Muscle. Mechanisms underlying cerebral vasospasm. Thermocycler with 96 well sample block for PCR reactions. Senior Brawn Research Support Fellowship. Gladys M Brawn Memorial Fellowships. Pacemaking in Smooth Muscle. Electrical pacemaking in smooth muscle. The development of sensory innervation to blood vessels.
Neurotransmitter release mechanism at the sympathetic neurovascular junction.
Publications
Spontaneous Excitation in Lymphatic Smooth Muscle. Union of Physiological Sciences', Glasgow, U. National Heart Foundation of Australia. Research Supervision Number of supervisions Completed Contact Details Email dirk. Department of physiology Organisation: University of Western Australia Description: Review RQF of the department for future planning.
Scopus - 3 Web of Science - 3. Wound tension and 'closability' with keystone flaps, V-Y flaps and primary closure: Phillip Jobling , Derek Laver. Scopus - 3 Web of Science - 4.
Helden - Wikipedia
Phillip Jobling , Eugene Nalivaiko. Scopus - 9 Web of Science - 7.
- The Heldan by Deborah Talmadge-Bickmore.
- Sketches from a Celestial Sea - One Drop.
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- Archaeological Conservation Using Polymers: Practical Applications for Organic Artifact Stabilization (Texas A&M University Anthropology Series).
Scopus - 11 Web of Science - Scopus - 18 Web of Science - Scopus - 27 Web of Science - Scopus - 13 Web of Science - 8. Derek Laver , Geoffrey Isbister. Scopus - 12 Web of Science - 9.
Gert-Jan van Helden
Tony Quail , Derek Laver. Scopus - 7 Web of Science - 6. Karen Kerr , Phillip Jobling. Scopus - 14 Web of Science - Rick Thorne , Derek Laver. Scopus - 13 Web of Science - Scopus - 23 Web of Science - Sally Mcfadden , Geoffrey Isbister. Heart pacemaking The lymphatic system Vascular mechanisms including the role of the endothelium and pericytes in various organs gastrointestinal tract, brain, lung etc. Smooth muscle mechanisms in the gastrointestinal and reproductive tracts. Brain mechanisms in health and disease Why did you get into research? What would be the ultimate goal for your research?
Digestive disorders remain a major health burden. First Aid for Cytotoxic Snakebite.
The effects of iron status on calcium handling systems in heart and brain. En Concierto , released in Ultravox's official fan page announced the Spies album would be released on CD for the first time with bonus material. The exact date was not mentioned, but it had been said to be in plans since As of now, the album remains officially unavailable. From Wikipedia, the free encyclopedia. Some of this article's listed sources may not be reliable. Please help this article by looking for better, more reliable sources. Unreliable citations may be challenged or deleted.
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