Symptomatic paroxysmal kinesigenic choreoathetosis as primary manifestation of multiple sclerosis. Motor pathway excitability in ATP13A2 mutation carriers: Evidence that gamma-secretase-mediated Notch signaling induces neuronal cell death via the nuclear factor-kappaB-Bclinteracting mediator of cell death pathway in ischemic stroke. Mechanisms and clinical implications of the placebo effect: The effect of treatment expectation on drug efficacy: European clinical guidelines for Tourette syndrome and other tic disorders.
Dynamics of regional distribution of ischemic lesions in middle cerebral artery trunk occlusion relates to collateral circulation. CD38 exacerbates focal cytokine production, postischemic inflammation and brain injury after focal cerebral ischemia. Nitroxyl in the central nervous system. Somatotopy of placebo analgesia is independent of spatial attention. The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems. Seventy years of episodic stiffness: Endocrine and immune substrates of depressive symptoms and fatigue in multiple sclerosis patients with comorbid major depression.
Mere surgery will not cure cluster headache--implications for neurostimulation. Intestinal ischemia-reperfusion injury leads to inflammatory changes in the brain. Nonsense mutations in SMPX, encoding a protein responsive to physical force, result in X-chromosomal hearing loss. MIA is a potential biomarker for tumour load in neurofibromatosis type 1. Pretreatment diffusion-weighted imaging lesion volume predicts favorable outcome after intravenous thrombolysis with tissue-type plasminogen activator in acute ischemic stroke.
Multiple enlarged nerves on neurosonography: Calorie restriction and stroke. Plexiform neurofibromas in children with neurofibromatosis type 1: Truncating mutations in THAP1 define the nuclear localization signal. Flexible cerebral connectivity patterns subserve contextual modulations of pain. Mechanisms involved in placebo and nocebo responses and implications for drug trials. Woher kommt die Ohnmacht? Was ist nun eigentlich zu tun bei Karotisstenosen? Harmlose Ohnmacht oder Gefahr in Verzug? Carotid plaque surface irregularity predicts cerebral embolism during carotid artery stenting.
Arm tremor in cervical dystonia--is it a manifestation of dystonia or essential tremor? Phenotypic spectrum of musician's dystonia: Emotional facial expressions modulate pain-induced beta and gamma oscillations in sensorimotor cortex. Treating pain with pain: Cancer stem cell-like cells derived from malignant peripheral nerve sheath tumors.
Playing with cardiac "redox switches": Delineation of the clinical phenotype associated with non-mosaic type-2 NF1 deletions: Large intragenic deletions of the NF2 gene: Mechanisms of oxidative glutamate toxicity: A novel third type of recurrent NF1 microdeletion mediated by nonallelic homologous recombination between LRRC37B-containing low-copy repeats in 17q Diffusion tensor imaging of the corpus callosum differentiates corticobasal syndrome from Parkinson's disease.
Transdermales Rotigotin bei M. Parkinson und Restless-Legs Syndrom. Multiple cerebral cavernous malformations and a novel CCM3 germline deletion in a German family. Cost of illness in patients with Gilles de la Tourette's syndrome. The new HNO donor, 1-nitrosocyclohexyl acetate, increases contractile force in normal and -adrenergically desensitized ventricular myocytes.
Patients with irritable bowel syndrome have altered emotional modulation of neural responses to visceral stimuli. Altered pattern of motor cortical activation-inhibition during voluntary movements in Tourette syndrome. Welcher Test bei Borrelienverdacht? Big news from small world networks after stroke. Monozygotic twins with neurofibromatosis type 1 NF1 display differences in methylation of NF1 gene promoter elements, 5' untranslated region, exon and intron 1. Oral delta 9-tetrahydrocannabinol improved refractory Gilles de la Tourette syndrome in an adolescent by increasing intracortical inhibition: Treating multiple sclerosis with information.
Autoimmunerkrankungen Heesen C, Gold S Springer Verlag Berlin Heidelberg: Wissenschaft kommentiert - Schlaganfall: Theta-gamma phase synchronization during memory matching in visual working memory. Gene expression analysis identifies potential biomarkers of neurofibromatosis type 1 including adrenomedullin. The truth about lying: Nonmotor symptoms in genetic Parkinson disease.
Impaired sense of smell and color discrimination in monogenic and idiopathic Parkinson's disease. What's new in neurofibromatosis? Proceedings from the NF Conference: Charting the excitability of premotor to motor connections while withholding or initiating a selected movement.
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Benefits and pitfalls of scientific research during undergraduate medical education. Lactacidosis modulates glutathione metabolism and oxidative glutamate toxicity. The involvement of the left motor cortex in learning of a novel action word lexicon. Images in cardiovascular medicine. Hypoglossal-nerve palsy caused by carotid dissection.
Clinical characterisation of 29 neurofibromatosis type-1 patients with molecularly ascertained 1. Radiographic regression of vestibular schwannomas induced by bevacizumab treatment: Health-related quality of life in patients with Gilles de la Tourette's syndrome. Diagnosis of Parkinson's disease--transcranial sonography in relation to MRI. Abnormal motor cortex plasticity in premanifest and very early manifest Huntington disease.
Is it a tic? Further support for a central component. Extended runs of homozygosity at 17q Intrachromosomal mitotic nonallelic homologous recombination is the major molecular mechanism underlying type-2 NF1 deletions. Diagnostic workup in carotid stenosis-a neurologist's perspective.
Secondary bleeding into a subacute carotid wall hematoma. Older age and greater carotid intima-media thickness predict ischemic events associated with carotid-artery stenting. Diagnosis, management, and complications of glomus tumours of the digits in neurofibromatosis type 1. We are on the clock: MRI as a surrogate marker of lesion age in acute ischemic stroke. Prediction of malignant middle cerebral artery infarction by magnetic resonance imaging within 6 hours of symptom onset: A prospective multicenter observational study.
Analysis of NF1 somatic mutations in cutaneous neurofibromas from patients with high tumor burden. A novel giant peroxisomal superoxide dismutase motif-containing protein. Imaging movement-related activity in medicated Parkin-associated and sporadic Parkinson's disease. Anterior insula integrates information about salience into perceptual decisions about pain. Clinical neuroimaging and electrophysiological assessment of three DYT6 dystonia families.
Neurogenesis in substantia nigra of parkinsonian brains? Thymectomy is more effective than conservative treatment for myasthenia gravis regarding outcome and clinical improvement. Inhibitory and facilitatory connectivity from ventral premotor to primary motor cortex in healthy humans at rest--a bifocal TMS study. MR spectroscopy MRS and magnetisation transfer imaging MTI , lesion load and clinical scores in early relapsing remitting multiple sclerosis: Sensory afferent inhibition within and between limbs in humans.
Involvement of motor pathways in corticobasal syndrome detected by diffusion tensor tractography. State of the Art — M. Therapie geriatrischer Patienten mit M. HNO exacerbates ischemic cerebral injury and oxidative neurotoxicity. Comparison of 10 perfusion MRI parameters in 97 subhour stroke patients using voxel-based receiver operating characteristics analysis.
Astrocytic dysfunction in epileptogenesis: Encephalopathy, visual disturbance and hearing loss-recognizing the symptoms of Susac syndrome. Monitoring Coordination during Bimanual Movements: Where Is the Mastermind? Dissociation between phase-locked and nonphase-locked alpha oscillations in a working memory task.
Temporal and spatial dynamics of cerebral immune cell accumulation in stroke. Human frontal midline theta and its synchronization to gamma during a verbal delayed match to sample task. Altered modulation of intracortical excitability during movement preparation in Gilles de la Tourette syndrome. Neoplastic meningitis from breast cancer: Facilitating skilled right hand motor function in older subjects by anodal polarization over the left primary motor cortex. Deficient intracortical inhibition SICI during movement preparation after chronic stroke. Structural Correlates of Functional Language Dominance: A Voxel-Based Morphometry Study.
Anti-endothelial serum antibodies in a patient with Susac's syndrome. Oscillatory mechanisms of process binding in memory. The functional relevance of phase reset: The visual evoked potential of surface alpha rhythm phase. Thrombolysis targeting MRI defined tissue at risk in minor stroke. Evidence for Distinct Neuropsychiatric and Personality Profiles. Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxone in vitro. Dimethylarginine dimethylaminohydrolase-1 transgenic mice are not protected from ischemic stroke.
Hemorrhaging focal encephalitis under fingolimod FTY treatment: Waking up the brain: Inducing homeostatic-like plasticity in human motor cortex through converging corticocortical inputs. Does an interspinous device Coflex improve the outcome of decompressive surgery in lumbar spinal stenosis?
One-year follow up of a prospective case control study of 60 patients. Neuroimaging the genomics of pain processing-a perspective. Affective neural circuitry and mind-body influences in asthma. Cerebral embolism during carotid artery stenting: A case-control study of sporadic Creutzfeldt-Jakob disease in Switzerland: Defective inhibition and inter-regional phase synchronization in pianists with musician's dystonia: Control mechanisms in working memory: Spontaneous locally restricted EEG alpha activity determines cortical excitability in the motor cortex.
Brain oscillatory substrates of visual short-term memory capacity. Abnormal motor cortex excitability in preclinical and very early Huntington's disease. Etiology of musician's dystonia: Quantitative t2 values predict time from symptom onset in acute stroke patients. Negative fluid-attenuated inversion recovery imaging identifies acute ischemic stroke at 3 hours or less.
Structural changes in the somatosensory system correlate with tic severity in Gilles de la Tourette syndrome. Mapping preclinical compensation in Parkinson's disease: Are cortical spreading depression and headache in migraine causally linked? Successful GPi deep brain stimulation in a patient with adult onset primary axial dystonia. Long-term outcome and quality of life after open and thoracoscopic thymectomy for myasthenia gravis: Observing repetitive finger movements modulates response times of auditorily cued finger movements.
Right hemisphere contributions to imitation tasks. Habituation to painful stimulation involves the antinociceptive system--a 1-year follow-up of 10 participants. Imaging CNS modulation of pain in humans. Bilateral idiopathic hypertrophy of the first dorsal interosseous muscles in a year-old man. Premotor transcranial direct current stimulation tDCS affects primary motor excitability in humans. Diagnostik und Therapie des M. Neuropsychiatric-developmental model for the expression of tics, pervasive developmental disorder, and schizophreniform symptomatology associated with PANDAS.
Targeting TNF-alpha receptors for neurotherapeutics. The importance of placebo in headache research. Frontal midline theta in the pre-shot phase of rifle shooting: Memory formation in the motor cortex ipsilateral to a training hand. Blockade of endogenous opioid neurotransmission enhances acquisition of conditioned fear in humans. Influence of somatosensory input on interhemispheric interactions in patients with chronic stroke. Functional similarities between the P1 component and alpha oscillations.
Alpha phase coupling reflects object recognition. Syntaxin 5 regulates the endoplasmic reticulum channel-release properties of polycystin Common neural systems for contact heat and laser pain stimulation reveal higher-level pain processing. EEG correlates of action observation in humans. Initial experience with ropinirole PR prolonged release. Low-frequency short-time nociceptive stimulation of the greater occipital nerve does not modulate the trigeminal system.
A short review of slow phase synchronization and memory: The cortical motor threshold reflects microstructural properties of cerebral white matter. Functional interplay between posterior parietal and ipsilateral motor cortex revealed by twin-coil transcranial magnetic stimulation during reach planning toward contralateral space.
Altered dorsal premotor-motor interhemispheric pathway activity in focal arm dystonia. Toll-like receptor 3 is a negative regulator of embryonic neural progenitor cell proliferation. Comparison of open versus percutaneous pedicle screw insertion in a sheep model. Walking the talk--speech activates the leg motor cortex. A novel approach to enhancing cellular glutathione levels. Transcranial ultrasound of the basal ganglia in sporadic Creutzfeldt-Jakob disease.
Disturbance of predictive response initiation of eye and head movements in cerebellar patients. Corticospinal system excitability at rest is associated with tic severity in tourette syndrome. REPAS, a summary rating scale for resistance to passive movement: Enhancement of long-range EEG coherence by synchronous bifocal transcranial magnetic stimulation. Management of cerebral arteriovenous malformations associated with symptomatic congestive intracranial hypertension.
What does phase information of oscillatory brain activity tell us about cognitive processes? Fragile X syndrome associated with tic disorders. Reduced perception of dyspnea and pain after right insular cortex lesions. T2' imaging predicts infarct growth beyond the acute diffusion-weighted imaging lesion in acute stroke. Heightened incidence of sporadic Creutzfeldt-Jakob disease is associated with a shift in clinicopathological profiles.
Changes in brain gray matter due to repetitive painful stimulation. Interleukin production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis.
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GLUT1 mutations are a cause of paroxysmal exertion-induced dyskinesias and induce hemolytic anemia by a cation leak. Long-term outcome after angioplasty of symptomatic internal carotid artery stenosis with and without stent. Citalopram improves dexterity in chronic stroke patients. Adult neurogenesis and Parkinson's disease. Intravenous immunoglobulin IVIG protects the brain against experimental stroke by preventing complement-mediated neuronal cell death.
Laterality of interhemispheric inhibition depends on handedness. Abnormal plasticity of the sensorimotor cortex to slow repetitive transcranial magnetic stimulation in patients with writer's cramp. Sensorimotor integration is abnormal in asymptomatic Parkin mutation carriers: Crossed cortico-spinal motor control after capsular stroke.
Klinik, Differentialdiagnostik und Therapie des M. Parkinson Buhmann C focus neurogeriatrie. Occipital nerve blockade in chronic cluster headache patients and functional connectivity between trigeminal and occipital nerves. Revisiting the astrocyte-oligodendrocyte relationship in the adult CNS. Disease progression after bone marrow transplantation in a model of multiple sclerosis is associated with chronic microglial and glial progenitor response.
Somatosensory stimulation enhances the effects of training functional hand tasks in patients with chronic stroke. Vagus nerve stimulation for treatment-resistant depression: Intermanual Differences in movement-related interhemispheric inhibition. Influence of cabergoline on motor excitability in patients with restless legs syndrome. Biological effects of the PINK1 c.
Participation preferences of patients with acute and chronic conditions. Pain, brain and consciousness: Stress and hypothalamic-pituitary-adrenal axis function in experimental autoimmune encephalomyelitis and multiple sclerosis - a review. Informed shared decision making in multiple sclerosis--inevitable or impossible? Shared decision making and self-management in multiple sclerosis--a consequence of evidence. Stress regulation in multiple sclerosis: Phenotypic spectrum of PINK1-associated parkinsonism in 15 mutation carriers from 1 family.
Observation of a finger or an object movement primes imitative responses differentially. Do simple intransitive finger movements consistently activate frontoparietal mirror neuron areas in humans? The effect of handedness on cortical motor activation during simple bilateral movements. Can left-handedness be switched? Insights from an early switch of handwriting. Focal stimulation of the posterior parietal cortex increases the excitability of the ipsilateral motor cortex. Autoimmune modulation of astrocyte-mediated homeostasis. Scanpaths in reading and picture viewing: Chronic dose effects of reboxetine on motor skill acquisition and cortical excitability.
Patterns of laminins and integrins in the embryonic ventricular zone of the CNS. Dementia and leukoencephalopathy due to lymphomatosis cerebri. Improvement of dexterity by single session low-frequency repetitive transcranial magnetic stimulation over the contralesional motor cortex in acute stroke: Evidence that nucleocytoplasmic Olig2 translocation mediates brain-injury-induced differentiation of glial precursors to astrocytes. Antineuronal antibody status and phenotype analysis in Tourette's syndrome. Autosomal dominant myoclonus-dystonia and Tourette syndrome in a family without linkage to the SGCE gene.
Dose-dependent attenuation of auditory phantom perception tinnitus by PET-guided repetitive transcranial magnetic stimulation. Moderate therapeutic efficacy of positron emission tomography-navigated repetitive transcranial magnetic stimulation for chronic tinnitus: Intravenous immunoglobulin in primary and secondary chronic progressive multiple sclerosis: Prediction of short-term and long-term outcomes after cardiac arrest: No effect of a levodopa single dose on motor performance and motor excitability in chronic stroke.
A double-blind placebo-controlled cross-over pilot study. Long-term follow-up of cerebral aneurysms after endovascular therapy prediction and outcome of retreatment. Dissociation of sustained attention from central executive functions: MRI-based and CT-based thrombolytic therapy in acute stroke within and beyond established time windows: Striatal grey matter increase in patients suffering from fibromyalgia--a voxel-based morphometry study.
Case report on fatal human rabies infection in Hamburg, Germany, March Acupuncture treatment improves nerve conduction in peripheral neuropathy. Alcohol as an alternative therapy in accommodative and convergence insufficiency. Neuroprotective actions of a histidine analogue in models of ischemic stroke. Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits. MRI study of acute stroke patients treated with intravenous tissue plasminogen activator within 6 hours.
Foveal versus parafoveal scanpaths of visual imagery in virtual hemianopic subjects. How to assess motor impairment in writer's cramp. Modulation of intracortical facilitatory circuits of the human primary motor cortex by digital nerve stimulation. Reboxetine improves motor function in chronic stroke. Immune stimulatory effects of CD70 override CDmediated immune cell apoptosis in rodent glioma models and confer long-lasting antiglioma immunity in vivo.
Magnetic stimulation of human premotor or motor cortex produces interhemispheric facilitation through distinct pathways. Acute encephalopathy due to glycerol over-consumption. Mechanisms of placebo analgesia: Encoding a motor memory in the older adult by action observation. The inositol 1,4,5-trisphosphate receptor IP3R and its regulators: Human transmissible spongiform encephalopathies in eleven countries: An update on functional neuroimaging of parkinsonism and dystonia.
Implementation of visuospatial cues in response selection.
Dopaminergic substantia nigra neurons project topographically organized to the subventricular zone and stimulate precursor cell proliferation in aged primates. Influence of gain of function epithelial chloride channel ClC-Kb mutation on hearing thresholds. Humanized mouse models for organ-specific autoimmune diseases. The value of animal models for drug development in multiple sclerosis. Coherent corticomuscular oscillations originate from primary motor cortex: Multimodal imaging of brain reorganization in motor areas of the contralesional hemisphere of well recovered patients after capsular stroke.
Stress and disease progression in multiple sclerosis and its animal models. Two different reorganization patterns after rehabilitative therapy: Repetitive transcranial magnetic stimulation to improve mood and motor function in Parkinson's disease. MEP latency shift after implantation of deep brain stimulation systems in the subthalamic nucleus in patients with advanced Parkinson's disease. Interregional long-range and short-range synchrony: Effects of brain polarization on reaction times and pinch force in chronic stroke.
Potassium channel dysfunction and depolarized resting membrane potential in a cell model of SCA3. Investigating the human mirror neuron system by means of cortical synchronization during the imitation of biological movements. Successful immunosuppressive treatment and long-term follow-up of anti-Ri-associated paraneoplastic myelitis. Motor cortex excitability in stroke before and after constraint-induced movement therapy.
The surround inhibition determines therapy-induced cortical reorganization. The role of multiple contralesional motor areas for complex hand movements after internal capsular lesion. Plastic changes in the human H-reflex pathway at rest following skillful cycling training. Transcranial grey-scale sonography of subdural haematoma in adults.
Friedrich Nietzsche's mental illness--general paralysis of the insane vs. The basal ganglia are hyperactive during the discrimination of tactile stimuli in writer's cramp. No effects of enhanced central norepinephrine on finger-sequence learning and attention. Saccade initiation in ocular motor apraxia. Spinocerebellar ataxia type 1, 2, and 3 and restless legs syndrome: The neuropeptide head activator is a high-affinity ligand for the orphan G-protein-coupled receptor GPR Behavioral and affective disorders in Tourette syndrome.
The amount of solid cerebral microemboli during carotid stenting does not relate to the frequency of silent ischemic lesions. CSF tests in the differential diagnosis of Creutzfeldt-Jakob disease. Beck Depression Inventory is a useful screening tool for major depressive disorder in Gilles de la Tourette syndrome.
Developing somatosensory projections bypass periventricular brain lesions. Extensive peri-lesional connectivity in congenital hemiparesis. Elevated levels of neural recognition molecule L1 in the cerebrospinal fluid of patients with Alzheimer disease and other dementia syndromes. New striatal dopamine neurons in MPTP-treated macaques result from a phenotypic shift and not neurogenesis.
Cerebral vasculitis following oral methylphenidate intake in an adult: Outcome and symptomatic bleeding complications of intravenous thrombolysis within 6 hours in MRI-selected stroke patients: Role of functional imaging in neurological disorders. Cortical excitability predicts seizures in acutely drug-reduced temporal lobe epilepsy patients. Characterizing physiological heterogeneity of infarction risk in acute human ischaemic stroke using MRI.
Clinical course in young patients with sporadic Creutzfeldt-Jakob disease. Motor reorganization in asymptomatic carriers of a single mutant Parkin allele: Vascular occlusion sites determine differences in lesion growth from early apparent diffusion coefficient lesion to final infarct. Future cooperation will focus on the exchange of scientific studies and the care of patients with complex cancers as well as the joint further development of patient pathways. Accordingly, I am very pleased that the network has been able to gain further expertise with this cooperation.
The newly founded Skin Tumor Center at the UCCH invited all patients, relatives and interested parties to its first information day on Wednesday, 29 August, on the topic "Detecting, avoiding and treating skin cancer". The experts from the Skin Tumor Center used the first information day organised by them not only to present themselves and the center to the public, but also to give interested parties an in-depth insight into the subject of skin cancer.
Accordingly, the lectures presented the latest findings from research on the numerous manifestations of skin cancer. The self-help group Hautkrebsnetzwerk Deutschland e. On site, the opportunity was taken to set up a regional self-help group, which will cooperate closely with the Skin Cancer Center in the future. In addition, the visitors could inform themselves about prevention possibilities and ask their own questions to the experts at the information stands.
The program was rounded off with the possibility of getting to know the skin clinic better during a guided tour. In order to counter the impending shortage of scientific specialists in oncology, the German Cancer Aid launched the funding programme to strengthen young scientists a year ago. The research excellence of the UKE has played an important role here", says Prof. Koch-Gromus is co-applicant of the concept developed by clinicians and scientists at the Hubertus Wald Tumorzentrum - University Cancer Center Hamburg UCCH to establish a junior research center in the field of tumor dissemination and metastasis.
In addition, the focus is on expanding the research infrastructure, setting up research grants and establishing mentoring programmes and career exchanges. About interested doctors were present at the 2nd Eppendorf Dermatology Symposium when the foundation of the new Skin Tumor Center was announced by the management team.
He is represented by Dr. Janina Staub and Thomas Haalck. Nina Booken is responsible for cutaneous lymphomas. The new Skin Tumor Center bundles the disciplines that make a modern therapy of all forms of skin tumors possible for our patients. We are primarily targeting high-risk patients in order to support the therapy especially in metastasis through clinical research and studies," says Prof.
Gebhardt, the new head of the Skin Tumor Center. Gebhardt's team in order to be a reliable contact for dermatooncological questions with the Skin Tumor Center," adds Prof. We are already actively working on the foundations for obtaining certification by the German Cancer Society in the next cycle in ". The consultation hours and further information, e. Schneider, Thomas Haalck, Prof. Despite many bad weather warnings: The weather held and also sent the sun in the afternoon. The aim of the funded project is to significantly improve the quality of life of cancer patients.
The regatta began with the most important highlight, the patient race. Three boats from Hamburg participated. All patients had previously taken part in the year-round rowing training for cancer patients, which has now been on offer for a year. The "Alsterchaoten" won with a remarkable performance, closely followed by the "Schlawiner". Another highlight of the day was the special race "Olympic Winner" against the "Medics". Kai Rothkamm and Priv. Alexander Stein had to admit defeat against the double Olympic gold medal winner.
They could book the revenge for themselves this year. The proud winners also finished 6th overall in the entry-level final. This time the teams "Ermel hoch" beginner and "Klabautermann" expert qualified for gold in the beginner and expert races. The "Martini" team 6th place experts from the UKE was also represented until the final. On the 25th and 26th of May this year, the time had come again: A comprehensive program of lectures, courses and opportunities to expand their own network awaited the numerous participants. In addition to the basic course according to AMG offered again after , one of the highlights this year was the key note on "Big Data in Clinical Research".
Due to increasingly complex study designs and highly individualized therapy approaches, this topic is becoming increasingly important in clinical research. In addition to the extensive scientific presentations of the respective UKE experts, Friday also offered the participants the opportunity to present their own study projects in an interdisciplinary environment and to enter into an in-depth discussion in the newly established Onco-Lounge.
The profitable workshop days were rounded off by a dinner followed by a get-together where all participants once again had the opportunity to talk to colleagues and experts. The UKE scientist receives the 10, Euro prize for his international commitment to the treatment of testicular carcinoma in young men. He was also awarded for his commitment to the further training of oncologists at European level and the further development of medical oncology in Germany. On 25 May, Prof. Germ cell tumors in men are rare cancers. In Germany there are about 4, new cases per year.
The treatment of patients with advanced germ cell walls has made considerable progress in recent years. Today, 80 to 90 percent of all patients with metastatic disease can be cured because they react extremely well to chemotherapy. Current research focuses on how high cure rates are achieved with few therapy side effects and why some patients are still resistant to the therapy and cannot be cured. Our goal is to further improve the prognosis of patients and to learn from it for other diseases and novel therapeutic approaches," says Prof.
His research group has conducted numerous multicenter clinical studies and a variety of basic research on resistance in germ cell tumors. For many years the group has also been intensively involved in the investigation and treatment of long-term consequences of therapy in cured patients within the framework of so-called survivorship programs. The UKE Medical Clinic is one of the national reference centers for the treatment of patients with advanced germ cell tumors of the testicles and is therefore recognized in the network of German cancer centers and the European centers for rare cancers.
The Wilhelm Warner Prize is awarded every year to renowned scientists in the field of cancer research. The Wilhelm Warner Foundation was founded in in Hamburg with the aim of promoting cancer research by awarding the Wilhelm Warner Prize annually to renowned scientists. Leukemia also known as "blood cancer" is a disease of the hematopoietic system.
Depending on which immature blood cells are affected by uncontrolled cell growth, they are called myeloid erythrocytes, granulocytes, monocytes or lymphatic leukemia lymphocytes. Both leukemias can occur in different forms - on the one hand in the acute form, which occurs suddenly and can lead to death within a few weeks, and on the other hand in the chronic form, which shows a slower course of the disease. During the conference in Hamburg it was possible to continue working together on new therapy concepts and study developments.
Ganser from the Hanover Medical School - have decided to hold the study meeting here in Hamburg this year," said Prof. Medical students actively use the elective modules offered. In the integrated model study programme Medicine Hamburg iMED , the theoretical basic subjects are networked with clinical practice and current research right from the start.
Students can choose their field of interest early on from 15 compulsory elective modules, the so-called second tracks. It is important to us to introduce the students to the topic and to provide insights from many different perspectives," says Prof. During the two-week elective courses for approx. The quality of our detailed offer can only be made possible by a well-functioning network such as the UCCH," says Prof. The figures confirm the success of the demanding oncology elective program: The 40 available places, which will be offered from the 5th semester for specialization in oncology in another 5 modules plus student research project, are always very popular and quickly allocated.
This concept of the reform study course is trend-setting for further structural planning of other medical study courses in Germany. Participation is free of charge, regardless of whether you would like to present a scientific presentation during your participation. On the website www. In addition, you will find information on how to apply for the UCCH Research Fellowship for assistant physicians interested in research and on the award of the Hubertus Wald Young Investigators Award for oncological research.
Great honour for the UCCH: The renowned Hamburg based cancer scientist Prof. Novel technologies and clinical applications". This congress is the world's largest meeting of cancer researchers with over 22, participants from all over the world. Pantel coined the term "Liquid Biopsy" eight years ago and not only presented his groundbreaking work in the field of circulating tumour cells and circulating cell-free tumour DNA, but also pointed out the relevant translational results he has achieved in consortia, partly led by the University Cancer Center Hamburg, on patient cohorts.
Research into mechanisms of metastasis and how they can be influenced is part of the translational vision of the University Cancer Center Hamburg, with which the center aims to significantly advance the treatment results for cancer patients over the next ten years. Bokemeyer, Director of the University Cancer Center: The funds received will enable the analyzation of relevant epidemiological studies on the risk of breast cancer and ovarian cancer.
This money allows UCCH staff to analyze relevant epidemiological studies around the risk of breast cancer and ovarian cancer. The findings will in turn form the basis for future prevention efforts," said Professor Chang-Claude, who will use the corresponding means for her investigations in a targeted manner. The winners have learned new things about which foods and preparations are especially recommended for cancer patients. Fresh herbs and spices have a variety of flavours, which means we can almost refrain from the use of salt. A lively discussion arose from the many questions.
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Counselling on nutrition topics in the context of the life after cancer consultation hours is open to all cancer patients. All cancer patients can now register for the new free course units under the motto "Making life sound". Music therapy opens up the possibility of perceiving and expressing oneself in a holistic way with the help of music. Experiencing the different facets of music, searching for and finding harmonious sounds and playing styles can lead to a better self-understanding.
This creates creative moments that open up new scope and perspectives. Further information on music therapy services. Interdisciplinary cooperation between surgery, endocrinology, gastroenterology, nuclear medicine, oncology, pathology and radiology has led to continuous improvements in the treatment of patients with this rare tumor disease. Under the direction of Dr. Medical Clinic and Prof. The UKE is the only center of excellence for this rare tumor disease in northern Germany.
With almost 12, experts, a new attendance record was set at the German Cancer Congress, which takes place every two years in Berlin. Oncologists, radiotherapists, surgeons and psychosocial doctors from the UCCH gave numerous lectures and led symposia. On Friday afternoon there was still time for a group photo and interdisciplinary knowledge exchange. The annual New Year's reception for the representatives of the more than 20 patient support groups cooperating with the UCCH has become an established and well-received tradition.
Also this year many participants accepted the invitation. New approaches and projects for the coming year were discussed in a lively exchange. Collaboration with the patient support groups is a central component of the patient-oriented work - for example, the first edition of the "Giving Help Together" patient support groups brochure was recently presented, which presents all information on self-help in the UCCH. Further information on the UCCH patient support groups. On February 1, patients, relatives and other interested parties were able to find out more about important topics in cancer medicine at the Erika House.
Changing a forced right-hander back to left-handed
The visitors experienced a varied programme of lectures, round-table discussions and information stands, which represented the wide range of the UCCH network. Lectures on personalized cancer medicine, therapy-accompanying possibilities such as complementary medicine, psycho-oncology, sports and nutrition as well as on the cornerstones of good doctor-patient communication were on the agenda.
In addition, experts from many disciplines were available to answer personal questions about the visitors own illness. The lucky winners were also happy about the successful participation in the cooking course raffle. Exceptional photos on the topic of familial breast and ovarian cancer can be seen from 17 January to 16 February at the Centre for Family Breast and Ovarian Cancer O24, Centre for Oncology.
The photographs of 17 women, taken from the book "Ansichtssache. Knowledge and decisions in familial breast and ovarian cancer" impressively show the handling with the diagnosis or knowledge of the risk of a disease. The exhibition will be opened on Wednesday, January 17, at 7. Every year, 75, women in Germany suffer from breast cancer and 8, women from ovarian cancer. Up to one-fifth of those affected have a genetic modification, for example, in the so-called BRCA genes breast cancer , which can also be passed on to their children. In these families, cancer is therefore much more common and often occurs at a very early age.
You can find further information about the work of the founded association BRCA-Network - Help with familial breast and ovarian cancer on the web at www. Further information about the event in German. The quartet also performs chamber music by Mozart and Brahms. Further information on the benefit event in German. Sonja Loges in cooperation with the Institute of Pathology, Prof.
The aim of the network is to offer comprehensive and high-quality molecular diagnostics for all patients with non-resectable, malignant lung cancer and thus promote the implementation of personalized therapy in routine clinical care. The network is the largest European platform for molecular diagnostics. Hubertus Wald Prize for Oncology awarded to prostate cancer researcher Prof. His long-standing commitment and outstanding achievements in the field of prostate cancer research were honored with this award. Bartels, Clinic for Otorhinolaryngology and Dr. Read the press release in German.
UKE - Neurology - Publications
More than 1, program items and several 1, visitors - the Night of Sciences on 4 November in Hamburg once again showed the impressive range of the science location Hamburg. Every two years, scientific institutions located in Hamburg present themselves and try to make their topics and works understandable in a playful way.
The UCCH also took part in the seven-hour long event with a large number of specialist disciplines. Numerous visitors of all ages learned about cancer diseases such as breast, skin and prostate cancer. In the children's rally, the children learned how to prevent cancer in general and enjoyed playing the specially developed UCCH prevention online memory.
The guided tours offered in the field of radiotherapy were used extensively, as was the laboratory of the II. Medical Clinic and Polyclinic for Hematology and Oncology. Further information on the event Night of Knowledge On the last weekend in October, a large number of interested practitioners gathered again to exchange information on current topics concerning palliative care and pain medicine in a multi-professional way. In the lectures and numerous workshops, new findings and treatment options for pain therapy and palliative care were presented and discussed. All in all, all participants were very satisfied with the exciting lectures, lively discussions and, above all, practical insights and experiences from the workshops.
Julia Quidde receives one of the Young Investigators' Awards for her work on quality of life in colon cancer patients. Doctors and scientists under 35 years of age had the opportunity to apply for the Young Investigators' Award by submitting an abstract. The works of the young scientists, that received the highest ratings from the reviewers, were selected for the prize. The works come with prize money of 1, euros each. In their opening speeches, Prof. Koch-Gromus underlined the important position of the cancer center in the UKE, which is now united under one roof.
Bokemeyer then presented the most important milestone events of last year to the nearly 60 cooperation partners from practice, clinic and research as well as patient support groups. All previous consultation hours and therapy-accompanying offers of the central entry port for patients and relatives continue to run in the new rooms as usual. Over 70 scientists and physicians met last weekend for 2 days to discuss their current cancer research projects, studies and publications.
Carsten Bokemeyer opened the event and pointed out the successful proposals and networking efforts in UCCH research. For me, the retreat was very impressive with many motivated scientists who presented high quality results. More than 40 lectures from more than 11 research fields show the active scientific activity in UCCH," says Prof. Such a vibrant network is the basis for successful research at the UCCH. The special feature of the retreat: The award winners as well as the award of research fellowships is chosen jointly by election," says Prof.
The prize winners for the young talent awards as well as the scholarship holders will be honoured at the upcoming Hubertus Wald Award Ceremony at the beginning of November. A total of beds are available for the young patients in bright and light rooms. The Kinder-UKE focuses on rare, complex and unexplained diseases.
Main areas of treatment are cancer, severe neurological and rare congenital diseases, metabolic diseases as well as liver, kidney and bone marrow transplants. It also houses the only oncological day clinic in the Hamburg metropolitan region. The diagnosis and treatment of children and adolescents with cancer or blood diseases is thus even more closely linked to the special fields involved", says Prof.
The move into the new building will begin on September 21st with ongoing operations, and all functional areas will be fully equipped from September 29th. A total of employees will work in the Kinder-UKE. A renowned cancer researcher of the UCCH was once again rewarded: This will support her research in the coming five years with a total of 1. Only in Prof. UKE researchers have received 14 of these coveted awards over the past years.
This underlines the markedly increased international competitiveness of the UKE. I am very delighted for Prof. The aim of the new research project of Prof. Loges is to use immunotherapeutic approaches to combat tumor cells that have remained in the bone marrow after treatment. In patients with initially curable cancer, the mortality rate is doubled when malignant cells remain in the bone marrow", explains the scientist. The reason why the human immune system does not recognize and eliminate the malignant cells remains an unsolved problem.
Loges and her team now want to analyze the interplay of bone marrow cells and immune cells to develop therapeutic strategies that enable the immune system to successfully fight the remaining cancer cells. Loges has recently proven how successful she can be in the field of therapy development: With her team, she has developed an inhibitor for the treatment of advanced acute myelogenous leukemia AML , which is now being tested for efficacy in an international clinical trial conducted by her.
The promotion of fundamental pioneering research is one of the main focuses of the European Union. ERC Grants are part of the EU's "Horizon " framework program, which funds both the fundamental research and application-oriented research fields. The total funding volume for the program, launched in , is around 70 billion euros by The objectives of the program are the further development of palliative medicine according to the national guidelines, the promotion of research with special research fellowships and the palliative medical training of oncologists and other specialists.
The recognition by the ESMO is a very gratifying result of the daily outstanding work of the entire multiprofessional palliative medicine team, as well as the good networking and collaboration with the oncological structures in the UCCH.
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The participation in the ESMO program will enable us to carry out network collaboration on a European level, which will provide important impulses for the care of oncological patients in the UCCH and the further development of palliative medicine in Hamburg, "says Prof. Passive smokers, like smokers, have an increased risk of developing lung cancer. However, the number of deaths from lung cancer attributable to passive smoking has declined over the past 20 years despite a generally aging population.
Heiko Becher, with the then current figures on this subject. The researchers assume that the decline is due to the increased protection of non-smokers since then. In , some 47, people have died of lung cancer. Among them were about 41, smokers and thus about 6, non-smokers. Based on these figures, the scientists have calculated that 7.
This figure fell significantly compared to — at that time it was Despite the aging population and a consequent increase in the total number of deaths of cancer, this means that significantly fewer deaths from lung cancer caused by passive smoking are registered than 20 years ago. In , a quarter of non-smoking women and about 40 per cent of non-smoking men were exposed to passive smoking. In , when a risk assessment of passive smoking was last carried out in Germany, about 60 per cent of men and 70 per cent of women were exposed to passive smoke, i.
More information about the Institute of Medical Biometry and Epidemiology. The goal is to raise public awareness for the risk factors of head and neck carcinomas and to provide information on possible therapeutic options. The Head and Neck Cancer Center of the UCCH also participated again this year with a patient day for interested visitors and patients and thus supported the worldwide efforts to focus on information and exchange on this topic. Numerous attendees followed the invitation and took the opportunity to inform themselves in short presentations, to explore the organ model of the oral cavity or to seek contact with self-help groups and medical experts.
The consultation offers for caring relatives and opportunities in palliative care were also used. In addition, the UCCH presented further offers such as complementary medicine counseling or the sports and exercise program for cancer patients, organized by the central entry port of the UCCH. The aim of the funded project is to significantly improve the quality of life for cancer patients.
In the end, the UCCH directors were "beaten" and took the silver medal in good spirits. The boats drove under great applause and close to each other over the finish line. Also included were two boast with the patients from Hamburg, who were able to prepare for the competition for the first time during the new rowing training, which is organized by the RG Hansa see news from March This time, the teams "MS Oh-nassis" beginners and "Braatzhammer" experts qualified for gold in the beginners' and expert races. The fantastic summer weather made the previous G20 riot forget.
This is Hamburg, the community spirit for the benefit of our patients — riots have no place in our city. The UKE has a new magazine: The patient magazine UKE Life is currently published for the first time. The magazine will be published quarterly. Press release in German. UKE receives endowed professorship for palliative medicine made possible by the Hamburg Cancer Society.
The head of palliative care at the UKE, Prof. Karin Oechsle, will be appointed to the new endowed professorship for palliative medicine with a research focus on relatives of cancer patients. It is financed by the Hamburg Cancer Society with one million euros over a period of five years. The overall goal is to accelerate research in the field of immunoncology.
The initiative is strongly supported by the company Bristol-Myers Squibb. In the treatment of cancer patients, immuno-therapeutic therapy approaches, which use the body's immune system for the defense of cancer, are currently used mainly in advanced stages. Hereby the capabilities of immunoncological treatment concepts for cancer patients are to be enhanced in the future. GECI has a particular focus on promoting academic research and networking at university oncological centers of excellence.
The newly launched study concepts for patients with head and neck tumors and with gastric carcinomas, which are currently being launched within the framework of a cooperation in Hamburg, are already geared towards the further development of immunotherapy in combination with chemotherapy and targeted therapy and irradiation. More than participants came to the Prostate Cancer Summit, which was hosted for the second time by the Martini Clinic at June 8th - 10th, here in Hamburg. The program focused on the most important topics in the treatment of prostate cancer, such as PSA screening, biomarkers, and the active monitoring and treatment of advanced prostate cancer.
The scientific high-caliber lectures in the various sessions were presented by international experts, among others, from the USA, Australia, Canada and Sweden. More information regarding the summit. More than 30, oncologists met in Chicago at the beginning of June to discuss the current state of research, diagnosis and treatment of cancer.
Important topics were the latest findings in cancer prevention, immuno-oncology and personalized cancer medicine. The UCCH was represented at the scientific level with numerous lectures, posters and abstracts. This is an important aspect for an oncological center of excellence of the German Cancer Aid", says Prof. Medical colleagues, who were unable to travel to the ASCO Congress themselves, can get information about the latest results of the congress at various events.
Calendar of events for physicians. On June 1st, patients, relatives and others interested were invited to a special patient day at the Hamburg Cancer Society. On the occasion of the "German Cancer Survivors Day", proclaimed by the German Cancer Foundation, awareness shall be raised annually for the situation of people who have been cured of cancer or live with a chronic cancer disease. The crowd was so big that many were not able to get a spot to participate.
The odds have never been so high to survive a cancer disease for a long time or be completely cured of it. For example, more than 3. But with the successful completion of a cancer therapy, many people are not as healthy as they once were before the illness. Many long-term survivors continue to suffer from physical, mental and social consequences for a long time.
These are dependent on the original cancer disease and its individual course as well as on the treatment and the side effects that came with it. Cancer survivors often suffer from fatigue, pain, sleep disorders, anxiety and worry, cognitive impairment and polyneuropathy. But also the handling of physical changes and limitations by e. Not to mention the financial difficulties in which many former cancer patients find themselves due to long breaks from work or even permanent occupational disability.
Discover the survivorship program of the UCCH. More information at the Hamburg Cancer Society in German. The oncologists from Egypt participated in the annual course for colorectal carcinomas, which was this year for the first time extended by ovarian carcinomas. Under the direction of Prof. Dirk Arnold and Prof. Barbara Schmalfeldt, the oncologists were informed about various aspects of medicine and research of colorectal and ovarian carcinomas. It was only last year that the palliative station at the UKE celebrated its 5th anniversary.
How palliative medicine can be implemented as an integral part of the care of incurably diseased oncological patients and their relatives at an early stage is being discussed more and more in recent years. Nevertheless, many questions have not yet been clarified in this context. Within the framework of the 4th Symposium on Palliative Medicine, these questions were looked at from a multiprofessional viewpoint in lectures and were actively discussed. Particular attention was given to the perspective of nurses, psychological aspects and the specific questions in the integrated oncological and palliative outpatient care.
Since the German Cancer Aid established the first hospice in Cologne in , it has now invested around EUR 70 million in the structure of palliative care in Germany. The CCC network, founded by the German Cancer Aid, and in particular the palliative medicine working group, is commissioned to strengthen these structures and to define and implement treatment concepts in collaboration with all parties involved.
Since the founding of the palliative medicine working group, major steps have already been taken. For example, a guide with empirically collected best practice recommendations on the integration of palliative medicine into the care of oncological patients at German CCCs will be published shortly. More Information can be found on the website of the German Cancer Aid in german. Fund for innovation supports after-care program for young cancer patients with 3. The abbreviation CAYA stands for children, adolescents and young adults. In the next two years, a federal consortium of 14 locations, headed by the UKE, is to be formed with help of the funding.
The goal of the consortium is to improve the networking of studies and treatment options for the benefit of young patients. Specifically, multi-professional and interdisciplinary teams of sports therapists, nutritional counselors and psycho oncologists are to be formed at the 14 locations throughout Germany, which together develop an individual prevention concept for cancer patients between 15 and 39 years of age.
The concept will include the topics nutrition and sports as well as psychosocial aspects to supplement the medical aftercare by hematologists and oncologists of pediatrics and adult medicine. It is therefore about the integrative prevention of long-term effects after a survived cancer disease at a young age.
The close co-operation and concrete agreement between all departments is thereby indispensable. Thanks to progress in the diagnosis and treatment of cancer diseases, the number of cancer survivors of all age groups is steadily increasing and is currently estimated at 2. A special group includes the patients between 15 and 39, that survived cancer in childhood, youth and as young adults.
The survival rates in this group of patients have also risen significantly in recent decades as a result of improved treatment options for cancer patients, so that the group of cancer survivors between 15 and 39 years is also continuously growing. This development increases the risk of long-term consequences, which can also occur decades after the therapy. Patients between the ages of 15 and 39 are particularly affected. Two-thirds of these patients develop follow-up diseases caused by the cancer therapy.
These can include physical problems e. They also have a significantly increased risk of suffering another cancer disease. As a rule, the patient is usually treated with a tumor aftercare, which is usually only performed by a doctor. After another successful and extensive review by an international expert group, the UCCH was once again recognized as an oncological center of excellence by the German Cancer Aid in July last year. The now third funding period starts on April 1st At the same time, the UCCH has reoriented itself in the management structure in order to be able to tackle the many diverse future tasks even more effectively.
As deputy directors, the following are responsible for specific tasks:. For as long as seven years now, the broad-based athletes and cancer patients have been training and rowing together for a good cause. This program is this year being expanded on the initiative of the foundation "Leben mit Krebs" with a year-long rowing training for cancer patients. Patients have the opportunity to take part in rowing training all year round with others, and to integrate into a rowing community. The training units are guided by experienced trainers. A large number of oncological patients have already accepted our sports programs with great enthusiasm, thanks to the extraordinary commitment of the foundation "Leben mit Krebs".
This is only because of the great joint commitment of all our members. The Krankenhaus Reinbek St.
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In addition, the St. Adolf-Stift Reinbek is an academic teaching hospital of the University of Hamburg. In the course of the focus area creation, the management composed of Prof. Important components in the cooperation are the joint development of treatment routes, the exchange concerning scientific studies and the care of patients with rare or complex cancer diseases.
More information regarding the Reinbek hospital can be found here in german. Testicular tumors are the most common malignant disease in young men. However, they can also be recognized very early in the process and can be cured in a large proportion of patients even in a very advanced disease situation. On the occasion of the testicular cancer action week of the German Society for Urology, the UKE team invited to a network meeting.
Patients and relatives were able to find out about the most important news. In addition the further interdisciplinary collaboration of the urogenital focus area, within the new funding period of the oncological center, was defined. The UKE has been offering an interdisciplinary consultation for patients with testicular tumors for more than ten years, in which oncologists and urologists jointly diagnose and plan the therapy — a unique model in Germany. In addition, the UCCH is a second assessment center for diseases in early stages www. The two hospitals on the North Sea coast of Schleswig-Holstein with their beds are considered to be one of the most important health centers in Schleswig-Holstein.
Joint objectives of the cooperation agreement are the cooperation in the definition of diagnostic and therapeutic procedures, the possibility of shared tumor boards and the exchange in the development of clinical studies. Together we can now jointly pursue our goals to optimize the patient's clinical care. Already at the beginning the participants noticed the fresh smell of many herbs.
Because the fresh herbs and spices have such an intensive aroma, we can almost cook without salt. The results of the cooking class were shared in a convivial gathering afterwards and the participants could gather more information on different aspects of nutrition. Further information on the survivorship counseling program. She is the patronage of the Friends Circle of the Outpatient Clinic for Psycho-Oncology and is actively involved in the charity events of the friends circle.
Later, when she was asked by his wife Beate Lause, if she likes to support the outpatient clinic for psycho-oncology, she enjoyed helping. Getting Hannelore Hoger as the patronage for the friends circle is a stroke of luck. This could be seen at her impressive and thrilling performance at the Erika Haus.
The reading was accompanied by the harpist Mariana Paccagnelle, who played a song from Marco Antonio Sumann from her hometown, and the choir of the friends circle. In the outpatient clinic for psycho-oncology cancer patients and their relatives will get support in difficult times by an interdisciplinary team consisting of psychologists, physicians and therapists.
They help in coping the stressing and side effects rich therapy, give handy daily help and offer a wide range of complementary treatments. Already after a few weeks the event and all workshops were fully booked out. In four different workshops participants could exchanges their views on family and cancer in small groups and in the afternoon there was a program including keynotes and speeches about the outpatient routine work and scientific research.
Georgia Schilling, managing director of the Hamburger Krebsgesellschaft. The conference shall take place annually with different focusses and demonstrates the broad cooperation within the network of the University Cancer Center Hamburg. The Hans-Dietrich Herrmann Lecture for Neuro-Oncology has got a different ankle each year, where topics are chosen in a rotating system from the three major scientific areas: Manfred Westphal, director of the clinic and policlinic for neuro-surgery invited Prof.
Antonio Chiocca as the speaker. Chiocca has got a teaching and researching position at the Harvard Medical School and currently president of the largest scientific organization for neuro-oncology — the Society for Neuro-Oncology. The University Medical Center Hamburg-Eppendorf is in close contact with his research laboratory, like sending post-graduated reseachers.
Although, neuro-surgery can tremendously developed in the last years, the perspective of patients with glioblastoma, a malignant brain tumor, is still unsatisfied.