Hemodialysis (Contributions to Nephrology)

This review article summarizes the current state-of-the-art on the subject. In this review we describe the results of omics studies carried out in IgAN patients.

We move from genomic studies focusing on common and rare variants linked to the disease, to transcriptomics carried out on circulating immune cells and kidney biopsy specimens and then to epigenomics, proteomics and metabolomics. The only member carrying both mutations developed C3GN. This study performed a pooled analysis of multiple phase 3 clinical trials to characterize the efficacy and safety of the SGLT2 inhibitor dapagliflozin in patients with type 2 diabetes with Stages 3b and 4 CKD.

Cases of symptomatic AVN were diagnosed by hip X-ray, radioisotope bone scan or magnetic resonance imaging.

The association of interdialytic blood pressure variability with cardiovascular events and all-cause mortality in haemodialysis patients. Watch more author videos from ndt. Inverse J-shaped relation between coronary arterial calcium density and mortality in advanced chronic kidney disease. Mortality and morbidity following exercise-based Renal Rehabilitation in patients with Chronic Kidney Disease: The effect of programme completion and change in exercise capacity. Explore a collection of highly cited articles from both ndt and ckj.

All of the featured articles have been published open access or made free to read online until the end of November Download from iTunes for free. Register to receive table of contents email alerts and advanced access email alerts to be the first to read the latest ndt content. Sign in, or register for an Oxford Academic account, to sign up. We have been researching an alternative method, selective PE, consisting of a membrane with smaller pores, which prevents large and essential molecules from being removed while removing waste from the patient's blood Apheresis for Kidney Disease.

Plasma exchange or double filtration plasmapheresis for rapidly progressive glomerulonephritis, and low-density lipoprotein LDL apheresis or leukocytapheresis for nephritic syndrome are two major apheresis therapies for kidney diseases. In addition to these apheresis therapies, plasma exchange for lupus nephritis or LDL apheresis for refractory focal segmental glomerulonephritis is clinically valuable and established.

Although several possibilities of apheresis for kidney diseases were speculated in animal experiments or human studies, clinical applications have thus far been limited Most of chronic renal disease patients receive 4-h hemodialysis HD sessions thrice a week.

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This is the minimum therapy needed to maintain life. This conventional HD therapy protocol is, however, inadequate to prevent dialysis-related complications.

On the other hand, some intensive HD therapies, such as "short daily dialysis," "quotidian dialysis," etc. Benefits, Risks, and Barriers. Home hemodialysis HHD has been available as a modality of renal replacement therapy since the s. HHD allows intensive dialysis such as nocturnal hemodialysis or short daily hemodialysis. Previous studies have shown that patients receiving HHD have an increased survival and better quality of life compared with those receiving in-center conventional HD.

However, HHD may increase the risk for specific complications such as vascular access complications, infection, loss of residual kidney function and patient and caregiver burden With CDDS, there is an improvement in work efficiency, reduction in cost, and a reduction in regional and institutional differences in dialysis conditions. This has resulted in an improvement in the survival rate throughout Japan. However, as the number of cases with various complications increases, it is necessary to select the optimal dialysis prescription including hours and frequency for each individual in order to further improve survival rates Improved biocompatibility of peritoneal dialysis solution PDS is crucial for peritoneal membrane preservation, thereby ensuring long-term peritoneal dialysis PD and preventing encapsulating peritoneal sclerosis.

We previously reported the protective effect of molecular hydrogen H2 on mesothelial cells from PDS in nonuremic rats. In the present study, we examined the effect of H2-containing PDS commercially available neutral pH type regarding the protection of peritoneal tissue in experimental chronic kidney disease rats Peritonitis is one of the most frequent reasons for withdrawal of peritoneal dialysis PD.

Although most cases of PD-related peritonitis can be treated with antibiotics, it is occasionally refractory and culture-negative. The causes of refractory PD-related peritonitis include antibiotic-resistant bacteria, fungal peritonitis, biofilm formation in PD catheters, bacterial translocation from the gastrointestinal tract, and encapsulating peritoneal sclerosis In dialysis patients, the definition is thought to be the same as in the general population.

But there is no clear description about the definition of HT for dialysis patients, especially in peritoneal dialysis PD patients. The prevalence of HT in PD patients is much higher compared to the general population. The association of BP and cardiovascular CV mortality in PD patients who are not exposed to huge hemodynamic changes during hemodialysis HD has been inconsistently reported Peritoneal Dialysis in Elderly Patients. Dialysis is now often being initiated in older patients. In Japan, patients are around 69 years of age on initiation of dialysis.

Under the current policy, there has been a move away from hospital-based care of elderly patients to home-based care. Here, in the context of this change, we describe the experiences of our elderly patients in initiating and maintaining PD In Japan, combined peritoneal dialysis PD and hemodialysis HD therapy is performed widely as an established modality of renal replacement therapy. This combination therapy is indicated for patients who cannot maintain adequate solute clearance using a standard PD prescription, or those who have uremic symptoms or a state of persistent fluid overload.

A 4- to 5-h HD session is performed with a high-flux membrane dialyzer Current State of Peritoneal Dialysis in Children. Recent statistics have revealed that the number of patients with preemptive kidney transplant KTx has increased to However, factors like body height, lack of kidney source, and severe complications render some patients ineligible for KTx. Peritoneal dialysis PD acts as the bridging therapy to KTx, especially for infants and young children.