Researchers had shown that infecting animals with purified prions could cause disease, but some still questioned whether a virus particle or two could have slipped undetected through the purification process.
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- Virus paper reignites prion spat - [PDF Document]?
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But in Prusiners lab showed that prions synthesized in a test tube and so free of virus could cause disease in mice2. A year later, Claudio Soto, a neurologist at the University of Texas in Galveston, selectively amplified prions from diseased mouse brains. He diluted his solutions until they could not contain any molecule from the brain sample other than prions.
Virus paper reignites prion spat
The solutions also infected mice3. I really feel that these viral people are swimming upstream, he says. But some highly regarded people do not think the prion hypothesis has been proven. The amount of synthetic prion needed to infect the mice was a million times higher than would be required using brain isolates.
And the mice were engineered to produce high amounts of the prions natural form, making them prone to developing prion disease spontaneously. If the synthetic prion can be shown to infect normal mice, Rohwer says he will be convinced. If its successful and can be reproduced by others, then it really does close the issue as far as Im concerned, he says. Prusiners results have not yet been verified by other labs, and some researchers have complained that the transgenic mice he used were not made available.
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Ilia Baskakov, a lead author on Prusiners paper who is now at the University of Maryland in Baltimore, says they used transgenic mice because these had the strongest response, but he hopes to replicate the work in wild-type animals soon. Baskakov says the synthetic prion probably had low activity because it was not folded into an optimally infectious form.
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