Potent pharmacological agents could prevent the first two processes, stents would prevent the third event and effective antiproliferative agents, ideally from the stent platform, could address the last process. This device would have limited use in native coronary arteries, however, due to the presence of many side branches and the occlusion of these branches by the graft material.
Alternatively, the angioplasty procedure may have to prevent only the recurrence of ischemia in the target vessel, even if the angioplasty site should become renarrowed. This approach may involve the drug-eluting stent and administration of antigenic growth factors or gene therapy to myocardium supplied by the treated vessel Thus, even if the stent should become restenosed, the angiogenesis in the target area may prevent the occurrence of ischemia and the need for repeat intervention.
Kundrecensioner
The restenosis process is an uncontrolled progression of the natural healing process. Thus, therapies aimed at allowing the necessary healing to occur i. With rapidly evolving technologies and continuing research, restenosis will be prevented in the majority of patients in the near future and the minority with restenosis still may benefit from a combination therapy aimed at preventing ischemia, not necessarily restenosis. National Center for Biotechnology Information , U.
Korean J Intern Med. Author information Copyright and License information Disclaimer. Address reprint requests to: Mechanisms of restenosis and potential treatments. Open in a separate window. Incidence of restenosis after successful coronary angioplasty: Restenosis after successful percutaneous transluminal coronary angioplasty: J Am Coll Cardiol. Restenosis after balloon angioplasty: Intimal proliferation of smooth muscle cells as an explanation for recurrent coronary artery stenosis after percutaneous transluminal coronary angioplasty.
Plaque morphology and pathologic changes in arteries from patients dying after coronary balloon angioplasty. Restenosis after coronary angioplasty. Current Problems in Cardiology. Local drug delivery for the prevention of restenosis: Effect of lesion characteristics on outcome of directional coronary atherectomy.
Relation of clinical presentation, restenosis morphology, and operator technique to the procedural results of rotational atherectomy and rotational atherectomy-facilitated angioplasty.
Percutaneous excimer laser coronary angioplasty of lesions not ideal for balloon angioplasty. Randomized comparison of angioplasty of complex coronary lesions at a single center: A comparison of directional atherectomy with coronary angioplasty in patients with coronary artery disease: N Engl J Med. Arterial remodeling after coronary angioplasty: A randomized comparison of coronary stent placement and balloon angioplasty in the treatment of coronary artery disease.
A comparison of balloon-expandable-stent implantation with balloon angioplasty in patients with coronary artery disease. Angiographic and clinical outcome following coronary stenting of small vessels. A comparison with coronary stenting of large vessels. Stented segment length as an independent predictor of restenosis. Patterns and mechanisms of instent restenosis: Intravascular ultrasound predictors of angiographic restenosis in lesions treated with Palmaz-Schatz stents.
Increased restenosis in diabetes mellitus after coronary interventions is due to exaggerated intimal hyperplasia. A serial intravascular ultrasound study. Intracoronary stenting without anticoagulation accomplished with intravascular ultrasound guidance.
Stent based sirolimus delivery reduces neointimal proliferation in a porcine coronary model of restenosis.
Current Problems in PTCA - Semantic Scholar
Stent-based delivery of sirolimus for the prevention of restenosis. Lack of neointimal proliferation after implantation of sirolimus-coated stents in human coronary arteries. A quantitative coronary angiography and three-dimensional intravascular ultrasound study.
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Catheter-based radiotherapy to inhibit restenosis after coronary stenting. Intracoronary gamma-radiation therapy after angioplasty inhibits recurrence in patients with in-stent restenosis. Localized intracoronary gamma-radiation therapy to inhibit the recurrence of restenosis after stenting. Inhibition of restenosis with beta-emitting radiotherapy: American College of Cardiology. Phase I assessment of direct intramyocardial administration of an adenovirus vector expressing VEGF cDNA to individuals with clinically significant severe coronary artery disease. Support Center Support Center. Please review our privacy policy.
Acute occlusion after percutaneous transluminal coronary angioplasty--a new approach.
Current Problems in Ptca (Hardcover, 1986 ed.)
Hollman , Andreas R. Gruentzig , John S. Douglas , Spencer B. Regional cardioplegia and cardioprotection during transluminal angioplasty, which role for nifedipine? Serruys , Marcel van den Brand , Ronald W. Brower , Paul G. Hugenholtz European heart journal A computer system for real time analysis of cardiac catheterization data. G T Meester , Nicolas. Bernard , Cees Zeelenberg , Ronald W.
Hugenholtz Catheterization and cardiovascular diagnosis Beat-to-beat analysis of cardiac catheterization data. Modeling the isovolumic relaxation period. Sudhakar Reddy , Robert Boudreau Catheterization and cardiovascular diagnosis