To look for new ways to control eating, scientists examined an enigmatic part of the brain known as the tuberal nucleus.
This area is located within the hypothalamus deep within the brain. It helps control hunger, thirst and body temperature, and also plays a role in sleep and emotion.
As such, Fu and his colleagues experimented with the mouse tuberal nucleus. Specifically, they focused on neurons that generated somatostatin, a hormone that helps control other hormones such as insulin. After mice were deprived of food overnight or were given the hunger hormone ghrelin, the scientists discovered that somatostatin neurons in the tuberal nucleus generated molecules that showed they were active, suggesting they may play a role in controlling feeding.
They also found that selectively activating and deactivating these neurons using either drugs or pulses of light could increase or decrease eating behavior, respectively. Totally eliminating these neurons resulted in reduced daily food intake and weight gain. Since this neural circuit is different from any other brain circuit linked to feeding, it presents a new target for controlling eating, hunger and weight. However, future research first needs to see if somatostatin neurons in the human tuberal nucleus functions the same way as it does in mice, he added.
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The scientists detailed their findings in the July 6 issue of the journal Science. You can contact our professionals any time.
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