The content of this book are easy to be understood. You that will drink digesting this book while spent your free time. Theexpression in this word brews the readership touch to scan and read this book again and repeatedly. Media it although you hope! Is that this magazine manipulate the prospects result? This book gives the readers many references and knowledge that bring positive influence in the future. It gives the readers good spirit. Although the content of this book aredifficult to be done in the real life, but it is still give good idea.
It makes the readers feel enjoy and still positive thinking. This book really gives you good thought that will very influence for the readers future. How to get thisbook? Getting this book is simple and easy. You can download the soft file of this book in this website. This website is available with pay and free online books. Plan for most the minutes until the get is terminate. This restful archive is disposed to visit as soon as you aim. Newer Post Older Post Home. From Creation to Commercial Growth and Change Advances in Tour Michael Albert and the Story of Partici Global Report on Human Se Explorations in Theory and Regulating Corporate Human Rights Violations: The Artisan Soda Workshop: Health and Safety at Work: The maths geniuses who brought down Wa Multiple Lenses on Loss Greatest Works of Alexandre Dumas: The Count of Mo Jung und gesund durch ein vitales Immunsystem: Problem Stories for Family Dis Vegetarian Appetizers, Desserts and Party Foods: The Journey of a Gay Minister Agriculture, Twelve Lectures on Agricultural Topic Clinical trials using cholesteryl ester transfer protein CETP inhibitors to raise high-density lipoprotein cholesterol HDL-C concentrations reported an 'off-target' blood pressure BP raising effect.
A multivessel cardiometabolic risk marker in women with T2DM. Although women have higher high-density lipoprotein cholesterol HDL-C than have men, their HDL particles are also prone to become small, dense, and dysfunctional in case of type 2 diabetes mellitus T2DM. This ratio estimates HDL sizes and provides indices as to their number, cholesterol load, and density. This ratio is a versatile and readily available marker of cardiometabolic status and vascular complications in T2DM women. Pathogen Inactivated Plasma Concentrated: This process functions by attacking the lipid sheathes that surround enveloped viruses.
Decreased maternal plasma apelin concentrations in preeclampsia. The development of preeclampsia has not been completely elucidated and current therapies are not broadly efficacious. The apelinergic system appears to be involved in hypertensive disorders and experimental studies indicate a role of this system in preeclampsia. Thus, an epidemiological evaluation of apelin protein concentration in plasma was conducted in case-control study of pregnant women. Concentrations of apelin peptides were blindly measured using enzyme-linked immunosorbent assay.
Data were subjected to statistical analyses. Reduced circulating apelin peptides may be associated with preeclampsia. The apelinergic system should be further investigated to elucidate its role in preclampsia and other hypertensive maternal disorders. Among the three groups, a plot of HDL-C vs. TG gave similar slopes but significantly different y-intercepts 9. Do plasma melatonin concentrations decline with age? Numerous reports that secretion of the putative sleep-promoting hormone melatonin declines with age have led to suggestions that melatonin replacement therapy be used to treat sleep problems in older patients.
We sought to reassess whether the endogenous circadian rhythm of plasma melatonin concentration changes with age in healthy drug-free adults. We analyzed the amplitude of plasma melatonin profiles during a constant routine in 34 healthy drug-free older subjects 20 women and 14 men, aged 65 to 81 years and compared them with 98 healthy drug-free young men aged 18 to 30 years.
These results do not support the hypothesis that reduction of plasma melatonin concentration is a general characteristic of healthy aging. Should melatonin replacement therapy or melatonin supplementation prove to be clinically useful, we recommend that an assessment of endogenous melatonin be carried out before such treatment is used in older patients. Triglyceride to high-density lipoprotein cholesterol HDL-C ratio and arterial stiffness in Japanese population: The present study was a cross-sectional study. Abdominal ultrasonography was used to diagnose fatty liver.
It was noted that the entire study was completed by Fukuda et al. The author only used this data for secondary analysis. The effect sizes and the confidence intervals on the left and right sides of inflection point were Effect of hemodialysis on leflunomide plasma concentrations. To report on the influence of hemodialysis on the disposition of leflunomide in a woman with end-stage renal disease. A year-old white woman with a history of diabetes, end-stage renal disease, rheumatoid arthritis, vasculitis, and leg ulcers was admitted to the hospital with a flare in the symptoms of joint pain and vasculitis.
Prior to admission, she had been treated for rheumatoid arthritis with methotrexate 7. Due to adverse effects from methotrexate and continuing painful joints, leflunomide was considered as a therapeutic alternative. A loading dose of mg was followed two days later by a daily dose of 10 mg. The active metabolite of leflunomide A was measured before and after hemodialysis and between hemodialysis sessions over a period of 80 days. Pre- and post-hemodialysis concentrations were compared for 17 sessions during this time.
It was shown that pre- and post-hemodialysis concentrations of A did not differ significantly. Thus, the low concentrations of A were not a result of the hemodialysis. Steady-state concentrations of A in plasma were not affected by hemodialysis or renal impairment. Reduction of the dose of leflunomide in patients with chronic renal failure undergoing hemodialysis does not appear to be required.
Both Lifestyle and Combined groups did not show significant changes in the atherogenic LDL-particles. A total of individuals including patients with low HDL-C disease and health subjects were analyzed based on matched for age, sex. Is it time to change? This definition, however, do not consider the population distribution of non- HDL-C , which could represent a more appropriate individual goal when both markers are discordant.
We also assessed the frequency of reclassification, defined as the number of subjects with LDL-C levels in the recommended therapeutic category, but with non- HDL-C levels above or below the category. Eggs are a source of cholesterol and choline and may impact plasma lipids and trimethylamine-N-oxide TMAO concentrations , which are biomarkers for cardiovascular disease CVD risk. Anthropometric data, blood pressure BP , dietary records, and plasma biomarkers lipids, glucose, choline, and TMAO were measured during each intervention phase.
BMI, waist circumference, systolic BP, plasma glucose, and plasma triacylglycerol did not change throughout the intervention. The hospital files of the patients were used to gather data. However, further large-scale prospective studies are required to establish the exact role of this simple, easily calculated, and reproducible parameter in the pathogenesis of ISR. Background-Low high-density lipoprotein cholesterol HDL-C is associated with an increased risk for atherosclerosis and concentrations are modulated by genetic and environmental factors such as smoking.
Objective- To assess whether the association of common single nucleotide polymorphisms SNPs Plasma magnesium concentration in patients undergoing coronary artery bypass grafting. Magnesium Mg plays a crucial role in cell physiology and its deficiency may cause many disorders which often require intensive treatment. The aim of this study was to analyse some factors affecting preoperative plasma Mg concentration in patients undergoing coronary artery bypass grafting CABG. Plasma Mg concentration was analysed before surgery in accordance with age, domicile, profession, tobacco smoking and preoperative Mg supplementation.
Blood samples were obtained from the radial artery just before the administration of anaesthesia. Mean preoperative plasma Mg concentration was 0. Moreover, intellectual workers supplemented Mg more frequently and had higher plasma Mg concentration than physical workers.
Plasma Mg concentration decreases in elderly patients. Patients living in cities, on average, had the highest plasma Mg concentration. Smokers had significantly lower plasma Mg concentration than non-smokers. Preoperative magnesium supplementation increases its plasma concentration. Intellectual workers frequently supplement magnesium.
Smoking cigarettes decreases plasma magnesium concentration. Background diet and fat type alters plasma lipoprotein response but not aortic cholesterol accumulation in F1B Golden Syrian hamsters. Dietary modification alters plasma lipoprotein profiles and atherosclerotic lesion progression in humans and some animal models. Variability in response to diet induced atherosclerosis has been reported in hamsters. Assessed was the interaction between background diet composition and dietary fat type on aortic cholesterol accumulation, lipoprotein profiles, hepatic lipids and selected genes. Plasma triacylglycerol concentrations in the hamsters fed the non-purified coconut oil-supplemented diets were three- to fourfold higher than non-purified safflower oil-supplemented, and both semi-purified diets.
Regardless of diet induced differences in lipoprotein profiles, there was no significant effect on aortic cholesterol accumulation. There was an inverse relationship between plasma n HDL-C and triacylglycerol, and hepatic cholesteryl ester content P concentrations.
Previous studies have shown that short-chain fatty acids SCFAs are capable of decreasing plasma cholesterol. However, the relative plasma -cholesterol-lowering activity of individual SCFAs and the underlying mechanisms by which SCFAs decrease plasma cholesterol remain largely unknown. The present study was done to compare the plasma -cholesterol-lowering potencies of four common SCFAs with carbons and to investigate their interactions with gene expressions of key regulatory factors involved in cholesterol metabolism.
For 6 weeks, five groups of male Golden hamsters were fed either a control high-cholesterol diet HCD or one of the four experimental HCDs containing 0. Seasonal variation in plasma sex steroid concentrations is common in mature vertebrates, and is occasionally seen in juvenile animals.
In this study, we examine the seasonal pattern of sex hormone concentration in juvenile American alligators Alligator mississippiensis and make We examined data from 1,, US individuals who were clinically referred for lipoprotein cholesterol ultracentrifugation Atherotech, Birmingham, AL from to Demographic information other than age and sex was not available.
The mean age of our study population was Levetiracetam concentration in the hair, which could reflect long-term drug exposure and patients' compliance, has not been systematically tested, as yet. The aim of this study was to determine the correlation between plasma , saliva, and hair levetiracetam concentrations in 47 patients with epilepsy.
Plasma , saliva, and hair levetiracetam concentrations were measured by liquid chromatography-tandem mass spectrometry with positive ionization. Plasma concentrations were not influenced by sex, age, and other concomitant antiepileptic drugs. Drug hair concentrations were not influenced by hair color or treatment dyed. The results tend to indicate that saliva may be a reliable alternative to plasma for monitoring levetiracetam concentrations. Levetiracetam can also be detected in human hair.
Cardiovascular disease CVD is a leading cause of death in the Philippines, although few studies here have examined the lipid profiles underlying disease risk. The isolated low high density lipoprotein cholesterol HDL-c phenotype has been implicated as a CVD risk factor, the prevalence of which exhibits significant variation across populations. We conducted multilinear regression models to assess the relationship between lipid components and BMI and dietary variables in the two populations.
We measured the prevalence of lipid phenotypes, and logistic regression models determined the predictors of the isolated low HDL-c phenotype. HDL-c was lower in the Philippines The prevalence of the isolated low HDL-c phenotype was Diet did not predict the low-HDL phenotype in Filipinos. Filipino women exhibit a high prevalence of the isolated low HDL-c phenotype, which is largely decoupled from anthropometric factors. The relationship of CVD to population variation in dyslipidemia and body composition needs further study, particularly in populations where the burden of cardiovascular and metabolic disease is rapidly increasing.
Effect of parvoviral enteritis on plasma citrulline concentration in dogs. Plasma citrulline concentration is a reliable marker of global enterocyte mass in humans and is markedly decreased in diffuse small intestinal diseases. However, the relationship between acute intestinal damage and plasma citrulline concentration in dogs has never been documented. That dogs with parvoviral enteritis have a lower plasma citrulline concentration than healthy dogs and that plasma citrulline concentration is a predictor of death in puppies with parvoviral enteritis.
Sixty-one dogs with spontaneous parvoviral enteritis and 14 healthy age-matched control dogs. Plasma citrulline concentration was measured by liquid chromatography and tandem mass spectrometry in blood samples collected at admission and each day until death or discharge from the hospital. Parvovirus enteritis was confirmed by electron microscopy on a fecal sample. Median interquartile range plasma citrulline concentrations at admission were 2. There were no significant changes in plasma citrulline concentration over the 8-day follow-up period.
Parvovirus enteritis is associated with a severe decrease in plasma citrulline concentration that does not appear to have any significant prognostic value. Plasma and skin vitamin E concentrations in canine atopic dermatitis. Altered homeostasis of vitamin E has been demonstrated in human atopic dermatitis. Data on plasma and skin vitamin E concentrations in canine atopic dermatitis CAD are not available.
To determine vitamin E concentrations in plasma and skin of atopic dogs. Vitamin E concentrations in plasma and full-thickness skin biopsies of 15 atopic dogs were related to CAD extent and severity index CADESI scores and compared to the equivalent concentrations in 17 healthy dogs. Statistically significant differences of measured parameters between the two groups were determined by the nonparametric Mann Whitney U test and correlations between CADESI scores and vitamin E concentrations were evaluated by the Spearman rank test.
A value of P Plasma concentrations of vitamin E were significantly lower in atopic dogs than in healthy dogs, with median values of Skin vitamin E values did not differ significantly between patients and healthy controls. The median concentration of skin vitamin E in atopic dogs was higher than that in healthy dogs.
Significantly lower plasma vitamin E concentrations in atopic dogs than in healthy controls indicate altered homeostasis of vitamin E in CAD. Further investigation into vitamin E supplementation in CAD is warranted. Ahmad, Tariq; Chasman, Daniel I. Background Recent genome-wide association studies have identified common variants associated with high-density lipoprotein cholesterol HDL-C.
Whether these associations are modified by physical activity, which increases HDL-C levels and reduces the risk of cardiovascular disease CVD , is uncertain. Methods and Results In a prospective cohort study of 22, apparently healthy Caucasian US women, we selected 58 single nucleotide polymorphisms SNPs in 9 genes that demonstrated genome-wide association P HDL-C levels and sought evidence of effect modification according to levels of physical activity PA. Compared to Caucasians, African Americans have lower TG levels and increased insulin levels despite a greater risk for diabetes.
IR was defined as the lowest tertile of SI 0. Background Admixture mapping of lipids was followed-up by family-based association analysis to identify variants for cardiovascular disease in African-Americans. Methods and Results The present study conducted admixture mapping analysis for total cholesterol, high-density lipoprotein cholesterol HDL-C , low-density lipoprotein cholesterol LDL-C and triglycerides. Regions showing admixture evidence were followed-up with family-based association analysis in 3, African-American subjects from the FBPP.
The admixture mapping and family-based association analyses were adjusted for age, age2, sex, body-mass-index, and genome-wide mean ancestry to minimize the confounding due to population stratification. Regions that were suggestive of local ancestry association evidence were found on chromosomes 7 LDL-C , 8 HDL-C , 14 triglycerides and 19 total cholesterol and triglycerides.
Dugi Guides Download - Dugi Guides
The family data was used in the fine-mapping to identify SNPs that showed novel associations with lipids and regions including genes with known associations for cardiovascular disease. Changes in plasma thrombospondin-1 concentrations following acute intracerebral hemorrhage. Angiogenesis is a fundamental process for brain development and repair.
Thrombospondin-1 is the first identified endogenous angiogenesis inhibitor. Its expression in rat brain is upregulated after intracerebral hemorrhage ICH. We determined whether plasma thrombospondin-1 concentrations are associated with injury severity and prognosis in ICH patients. This observational, prospective study recruited patients and age- and gender-matched healthy controls. Blood samples were collected from the patients at admission and from the healthy controls at study entry to measure plasma thrombospondin-1 concentrations.
Plasma thrombospondin-1 concentrations were markedly higher in patients than in healthy controls. Thrombospondin-1 was an independent predictive factor for all endpoints and plasma thrombospondin-1 concentrations were highly associated with injury severity reflected by hematoma volume and National Institutes of Health Stroke Scale score.
Under receiver operating characteristic curves, plasma thrombospondin-1 concentrations had similar predictive values compared with hematoma volume and National Institutes of Health Stroke Scale score. Increased plasma thrombospondin-1 concentrations following ICH are independently associated with injury severity and short-term and long-term clinical outcomes. Salivary caffeine concentrations are comparable to plasma concentrations in preterm infants receiving extended caffeine therapy.
Liu, Xiaoxi; Rhein, Lawrence M. Aims Caffeine concentrations in preterm infants are usually measured in the blood. However, salivary assays may provide a valid and practical alternative. Methods Paired salivary and plasma samples were obtained in 29 infants. Salivary samples were obtained using a commercially available salivary collection system. Paired samples were obtained at a mean postmenstrual age PMA of The range of plasma caffeine concentrations was 9. Salivary concentrations correlate highly with plasma concentrations. Low plasma triiodothyronine concentrations and outcome in preterm infants.
A major association has been found between low plasma triiodothyronine concentrations in preterm neonates and their later developmental outcome. Plasma triiodothyronine concentration was measured longitudinally in preterm infants below g birth weight. Babies whose lowest recorded concentration was less than 0. Low concentrations of triiodothyronine were strongly associated with infant mortality, but not after adjusting for the presence of respiratory illness.
There was no association between plasma triiodothyronine concentrations and somatic growth up to 18 months, and no association with necrotising enterocolitis or later cerebral palsy. Data on postnatal changes in plasma triiodothyronine concentrations are presented for reference purposes. While cited reference ranges for plasma triiodothyronine concentration appear suitable for well infants above g birth weight, smaller or ill babies often have very low values for many weeks.
Our data are relevant to the debate on endocrine 'replacement' treatment in premature babies. Insulin resistance IR is an important clinical issue in patients with type 1 diabetes due to worse metabolic control and risk of development of chronic complications. The aim of the study was to evaluate simple and easily available parameters as indirect markers of IR in adults with type 1 diabetes and correlate it with the results of hyperinsulinemic-euglycemic clamp.
The study included 88 patients 62 men , aged Tissue sensitivity to insulin was assessed on the basis of glucose distribution rate GDR obtained in the course of hyperinsulinemic-euglycemic clamp. Published by Elsevier Inc. Women of African descent have a high prevalence of diseases caused by insulin resistance. To positively impact cardiometabolic health in Black women, effective screening tests for insulin resistance must be identified. While the ratio predicts insulin resistance in White women, it is ineffective in African American women.
For comparison, the ratio was also tested in White women from South Africa. Standardized scores were created from log-transformed homeostasis model assessment-insulin resistance values from each population. Participants in the upper third of their population distribution were classified as insulin-resistant. Resources to identify effective markers of insulin resistance are needed to improve cardiometabolic health in women of African descent.
We aimed to test the statistical association of ABO locus variants with lipid profiles and levels of thirteen inflammatory markers in a Taiwanese population. A sample population of Taiwanese subjects was enrolled. Five ABO gene region polymorphisms were selected and genotyped. These results provided further evidence for the mechanism in the association of ABO blood groups with atherosclerotic cardiovascular diseases.
Plasma concentrations of retinol in obese children and adolescents: To evaluate obese children and adolescents' retinol plasma levels and to correlate them with metabolic syndrome components. Pubertal development, arterial blood pressure, body weight and height for nutritional classification and waist circumference were obtained.
A 15mL blood sample was collected after a hour fasting in a low luminosity room for retinol determination cut-off inadequate if HDL-c , LDL-c, and triglycerides , oral glucose tolerance test fasting and minutes and for high sensitivity C-reactive protein. Spearman correlation and multiple linear regression were used in the statistical analysis. Mean age was The average plasmatic retinol was An independent and inverse association between plasma retinol levels and glucose tolerance was observed, suggesting an important contribution of this vitamin in the morbidities associated to obesity in children and adolescents.
Control of exogenous factors affecting plasma homovanillic acid concentration. Measurements of plasma homovanillic acid pHVA concentrations appear to be a valid research strategy in psychiatric disorders in which a central dopamine DA abnormality has been implicated. This study provides guidance about the control of some of the exogenous factors affecting pHVA concentrations. Fasting for 14 hours eliminates the dietary effects on pHVA in healthy human subjects. Changing position, walking for 30 minutes, or smoking two cigarettes has no effect on pHVA concentrations. Altering plasma sodium concentration rapidly changes blood pressure during haemodialysis.
Plasma sodium is increased following each meal containing salt. There is an increasing interest in the effects of plasma sodium concentration , and it has been suggested that it may have direct effects on blood pressure BP and possibly influences endothelial function. Experimental increases of plasma sodium concentration rapidly raise BP even when extracellular volume falls.
Ten patients with end-stage renal failure established on haemodialysis were studied during the first 2 h of dialysis without fluid removal during this period.
BP measurements and blood samples were taken every 30 min. Lipaemic plasma induces haemolysis in resuspended red cell concentrate. We also investigated whether haemolysis was affected by the conditions under which lipaemic plasma was stored. Fresh plasma was aliquoted into ml tubes and stored in one of four ways as follows: A sample of RCC was resuspended in each of these plasmas and haemolysis measured after 2 h. Plasma was separated into top, middle and bottom fractions and used to resuspend RCC that were assessed for haemolysis after 2 h.
This was irrespective of whether plasma was MB treated. Lipaemic plasma stored frozen and then thawed resulted in the greatest haemolysis. Haemolysis in red cells is increased in those suspended in lipaemic plasma and is dependent upon the storage conditions of that plasma prior to suspension. These data are relevant to the choice of plasma used to suspend red cells for neonatal exchange transfusion.
An annotation-based genome-wide association study. Although numbers of genome-wide association studies GWAS have been performed for serum lipid levels, limited heritability has been explained. Studies showed that combining data from GWAS and expression quantitative trait loci eQTLs signals can both enhance the discovery of trait-associated SNPs and gain a better understanding of the mechanism.
We performed an annotation-based, multistage genome-wide screening for serum-lipid-level-associated loci in totally Han Chinese. A serum high-density lipoprotein cholesterol HDL-C associated variant rs hg19 chr7: After the replication, an active segment covering variants tagged by rs near 5' of DAGLB was annotated using histone modification and transcription factor binding signals. The luciferase report assay revealed that the segment containing the minor alleles showed increased transcriptional activity compared with segment contains the major alleles, which was consistent with the eQTL analyses.
Integrated analyses established a genotype-gene-phenotype three-way association and expanded our knowledge of DAGLB in lipid metabolism. Low serum levels of High-Density Lipoprotein cholesterol HDL-c as an indicator for the development of severe postpartum depressive symptoms.
Serum lipid levels have been related to depressive disorders, but very limited literatures are available regarding the lipid levels in women with postpartum depression. The present study is aimed to examine the association of serum lipids with the development of postpartum depressive symptoms. This is a cross sectional study conducted at a tertiary care hospital in South India. Women who came for postpartum check-up at 6th week post-delivery were screened for PPD September October The study involved cases and controls matched for age and BMI.
Serum levels of lipid parameters were estimated through spectrophotometry and the atherogenic indices were calculated in all the subjects. Our study demonstrated that low levels of serum HDL-c is correlated with the development of severe depressive symptoms in postpartum women. Study highlights the role of lipids in the development of postpartum depressive symptoms.
We also investigated linked pedigrees in each region using by-pedigree analysis. Results Fourteen regions with at least suggestive linkage evidence were identified, including some that may increase and some that may decrease coronary risk. Ten of the 14 regions were identified by more than one analysis, and several of these regions were not previously detected.
plasma hdl-c concentration: Topics by theranchhands.com
By-pedigree multi-point LOD values in MCLINK showed linked pedigrees for all five regions, ranging from 3 linked pedigrees chromosome 5 to 14 linked pedigrees chromosome 7 , and suggested localizations of between 9 cM and 27 cM in size. Conclusion Reasonable concordance was found across analysis methods. No single method identified all regions, either by full sample LOD or with by-pedigree analysis.
Concordance across methods appeared better at the pedigree level, with many regions showing by-pedigree support in MCLINK when no evidence was observed in the full sample. Thus, investigating by-pedigree linkage evidence may provide a useful tool for evaluating linkage regions. Fourteen regions with at least suggestive linkage evidence were identified, including some that may increase and some that may decrease coronary risk. Reasonable concordance was found across analysis methods. Plasma procalcitonin concentrations are increased in dogs with sepsis. Sepsis, the life-threatening organ dysfunction caused by a dysregulated host response to infection, is difficult to identify and to prognosticate for.
In people with sepsis, procalcitonin PCT measurement aids diagnosis, enables therapeutic monitoring and improves prognostic accuracy. Before analysing canine plasma samples, the ability of the assay to identify canine PCT, in addition to assay imprecision and the lower limit of detection were established. The lower limit of detection was 3. Dogs with sepsis have significantly increased plasma PCT concentrations compared with healthy dogs, although considerable overlap between these populations was identified.
Future investigations should confirm this finding in other populations and evaluate the diagnostic and prognostic value of PCT in dogs with sepsis. Use of refractometry for determination of psittacine plasma protein concentration. Previous studies have demonstrated both poor and good correlation of total protein concentrations in various avian species using refractometry and biuret methodologies. The purpose of the current study was to compare these 2 techniques of total protein determination using plasma samples from several psittacine species and to determine the effect of cholesterol and other solutes on refractometry results.
Total protein concentration in heparinized plasma samples without visible lipemia was analyzed by refractometry and an automated biuret method on a dry reagent analyzer Ortho Cholesterol, glucose, and uric acid concentrations were measured using the same analyzer. Results were compared using Deming regression analysis, Bland-Altman bias plots, and Spearman's rank correlation. Correlation coefficients r for total protein results by refractometry and biuret methods were 0. Method and species-specific reference intervals should be used in the interpretation of total protein values.
Sixty T2DM patients without insulin treatment at baseline were included in the 6-year cohort study. Baseline demographic characteristics, clinical variables between two groups were compared. There was no significant difference in DNA telomere length between the two groups. Change in DNA telomere length over 6 years was not significantly correlated with baseline blood lipid. It may be a simple index to predict progression speed of islet beta cell dysfunction. Choline concentrations are lower in postnatal plasma of preterm infants than in cord plasma.
Choline is essential to human development, particularly of the brain in the form of phosphatidylcholine, sphingomyelin and acetylcholine, for bile and lipoprotein formation, and as a methyl group donator. Choline is actively transported into the fetus, and maternal supply correlates with cognitive outcome.
Interruption of placental supply may therefore impair choline homeostasis in preterm infants. Determination of postnatal plasma concentrations of choline and its derivatives betaine and dimethylglycine DMG in preterm infants compared to cord and maternal blood matched for postmenstrual age PMA. Cord plasma choline concentration was In term but not in preterm infants, cord plasma choline was lower in girls than in boys.
Prenatal glucocorticoid treatment did not affect choline levels in cord plasma , whereas betaine was decreased and DMG increased. In parturients and non-pregnant women, choline concentrations were After delivery, preterm infant plasma choline decreased to Betaine and DMG correlated with plasma choline in all groups. Maternal plasma cholesterol and duration of pregnancy: A prospective cohort study in Ghana. Low plasma cholesterol may be associated with preterm birth; however, results are mixed and limited primarily to high-income countries.
Our objective was to determine whether maternal plasma lipid concentrations are associated with pregnancy duration. Pregnancy duration was 4. Our data suggest that low HDL-C in the third trimester of pregnancy is associated with a shorter duration of pregnancy in this study population but do not support the hypothesis that low total cholesterol is associated with a shorter pregnancy duration. Measurement of plasma homovanillic acid concentrations in schizophrenic patients. Several lines of evidence suggest that abnormalities of central dopaminergic transmission may be involved in the expression of some schizophrenic symptoms.
However, elucidation of the role of dopamine DA in schizophrenia has eluded investigative efforts partially because no accurate and easily repeatable measure of brain DA activity exists. The development of a technique to measure homovanillic acid in plasma has offered the possibility of performing serial measurements of this major DA metabolite. Results to date suggest that plasma homovanillic acid concentrations are lower in chronic schizophrenic patients compared to normal controls, and that PHVA values correlate with schizophrenic symptom severity.
In addition, PHVA levels were shown to initially rise and subsequently decline during chronic neuroleptic administration in treatment responsive but not in treatment refractory schizophrenic patients. Relationship between the concentrations of plasma phospholipid stearic acid and plasma lipoprotein lipids in healthy men. Both the ovolacto vegetarian and vegan groups demonstrated significant decreases in plasma total cholesterol TC , low-density-lipoprotein cholesterol LDL-C and triacylglycerol concentrations compared with both the high-meat-eater and moderate-meat-eater groups.
Bivariate analysis of the results showed that the plasma PL stearic acid concentration was strongly positively correlated with plasma TC P plasma PL myristic acid, palmitic acid and arachidic acid, and dietary total fat, saturated fat, cholesterol, carbohydrate and fibre intake , the plasma PL stearic acid concentration was still strongly positively correlated with plasma TC P concentrations.
Based on the present data, it would seem appropriate for the population to reduce their dietary total SFA intake rather than to replace other SFA with stearic acid. Plasma drug concentrations and physiological measures in 'dance party' participants. The present study sought to address this question. Plasma MDMA concentrations , vital signs, and a variety of blood and urine measures were obtained prior to, and hours after, individuals attended a dance party. After the dance party, subjects were without clinical complaints, had measurable amounts of residual MDMA in plasma , and nearly half of the subjects also tested positive for methamphetamine, another amphetamine analog that has been shown to have 5-HT neurotoxic potential in animals.
Plasma concentrations of MDMA did not correlate with self-reported use of 'ecstasy' and, in some subjects, overlapped with those that have been associated with 5-HT neurotoxicity in non-human primates. Additional subjects were likely to have had similar concentrations while at the dance party, when one considers the reported time of drug ingestion and the plasma half-life of MDMA in humans.
Hematological and biochemical analyses were generally unremarkable. Moderate increases in blood pressure, heart rate and body temperature were observed in the subjects with the highest MDMA plasma concentrations. These findings are consistent with epidemiological findings that most people who use MDMA at dance parties do not develop serious clinical complications, and suggest that some of these individuals may be at risk for developing MDMA-induced toxicity to brain serotonin neurons. Background High-density lipoprotein cholesterol HDL-C and triglycerides are cardiovascular risk factors susceptible to lifestyle behavior modification and genetics.
We hypothesized that genetic variants identified by genome-wide association studies GWASs as associated with HDL-C or triglyceride levels will modify 1-year treatment response to an intensive lifestyle intervention ILI , relative to a usual care of diabetes support and education DSE. Anthropogenic nitrogen is a ubiquitous environmental contaminant that is contributing to the degradation of freshwater, estuarine, and coastal ecosystems worldwide.
The effects of environmental nitrate, a principal form of nitrogen, on the health of aquatic life is of increasing concern. We exposed female American alligators to three concentrations of nitrate 0. Plasma and urinary nitrate concentrations increased with increasing nitrate treatment levels, although relative plasma concentrations of nitrate were significantly lower in five month, versus five week old animals, possibly due to improved kidney function in older animals. These results indicate that environmentally relevant concentrations of nitrate can increase circulating concentrations of T in young female alligators.
Continuous glucose monitoring CGM accuracy during hypoglycemia is suboptimal. This might be partly explained by insulin or hypoglycemia-induced changes in the plasma interstitial subcutaneous SC fluid glucose gradient. The aim of the present study was to assess the role of plasma insulin PI and hypoglycemia itself in the plasma and interstitial SC fluid glucose concentration in patients with type 1 diabetes mellitus.
Eleven subjects with type 1 diabetes age Each subject underwent two randomized crossover clamps with either a primed 0. The raw CGM signal was normalized with median preclamp values to obtain a standardized measure of the interstitial glucose IG concentration before statistical analysis. In contrast, no difference was observed during hypoglycemia. The subjects were Mexican mestizos who resided in Puebla City, Mexico, who were anthropometrically, biochemically, and clinically characterized.
The study included subjects, with an average age of Previous studies have reported that the triacylglycerol TG level and high-density lipoprotein cholesterol HDL-C are connected with breast cancer. The neuropeptides oxytocin OT and arginine vasopressin AVP play important and interrelated roles in modulating mammalian social behaviour. While the OT system has received considerable research attention for its potential to treat psychiatric symptoms, comparatively little is known about the role of the AVP system in human social behaviour.
To better understand the intraindividual stability of basal AVP, the present study assessed the reproducibility of basal plasma AVP concentrations. Basal plasma AVP was assessed at four sampling points separated by 8 days, on average, in 16 healthy adult males. Only one out of six comparisons revealed strong evidence for reproducibility of basal AVP concentrations visit 2 vs. The concordance correlation coefficient [0. Poor reliability of basal AVP concentrations suggests future work covarying AVP with trait markers should proceed with careful consideration of intraindividual fluctuations.
Plasma cytokine concentrations in dogs with a congenital portosystemic shunt. Congenital portosystemic shunts cPSS are a well-recognised vascular anomaly in dogs. Recent studies have shown an association between inflammation and hepatic encephalopathy HE , which is a common clinical syndrome in dogs with a cPSS. Logistic regression models and accurate estimates of the areas under receiver operating characteristic curves AUROC were obtained.
None of the lipid ratios was associated with early-phase insulin secretion. Laser system for measuring small changes in plasma tracer concentrations. The authors developed a laser-diode system that can be used for on-line optical concentration measurements in physiologic systems. Previous optical systems applied to whole blood have been hampered by artifacts introduced by red blood cells RBCs. The system introduced here uses a commercially available filter cartridge to separate RBCs from plasma before plasma concentration measurements are made at a single wavelength.
The filtering characteristics of the Cellco filter cartridge , German-town, MD were adequate for use in the on-line measurement system. The response time of the filter cartridge was less than 40 seconds, and the sieving characteristics of the filter for macromolecules were excellent, with filtrate-to- plasma albumin ratios of 0.
The nm laser diode system developed was shown to be more sensitive than the spectrophotometer used in previous studies Klaesner et al. The new system was used to measure the product of filtration coefficient Kfc and reflection coefficient for albumin delta f in an isolated canine lung preparation. Thus, this new optical system was shown to accurately measure plasma concentration changes in whole blood for physiologic levels of Kfc.
The same system can be used with different optical tracers and different source wavelengths to make optical plasma concentration measurements for other physiologic applications. Drug concentrations in post-mortem femoral blood compared with therapeutic concentrations in plasma. Therapeutic drug concentrations measured in plasma are of limited value as reference intervals for interpretation in post-mortem PM toxicology.
In this study, drug concentration distributions were studied in PM femoral venous blood from 57 Finnish autopsy cases representing all causes of death during an year period. Cause-of-death information was obtained from death certificates issued by forensic pathologists. Median, mean, and upper percentile 90th, 95th, These drug concentration distributions based on a large database provide a helpful reference not only to forensic toxicologists and pathologists but also to clinical pharmacologists in charge of interpreting drug concentrations in PM cases.
Social regulation of plasma estradiol concentration in a female anuran. The behavior of an individual within a social aggregation profoundly influences behavior and physiology of other animals within the aggregation in such a way that these social interactions can enhance reproductive success, survival and fitness. This phenomenon is particularly important during the breeding season when males and female must synchronize their reproductive efforts.
We compared plasma estradiol and androgen concentrations in wild-caught females before and after exposure to either natural mate choruses or random tones.
After exposure to mate choruses for 10 consecutive nights, estradiol concentrations were significantly elevated whereas there was no significant elevation in estradiol concentrations in the group of females exposed to random tones for 10 nights. Plasma androgen concentrations were not significantly changed after exposure to either natural mate choruses or random tones for 10 consecutive nights. To our knowledge, this is the first study to demonstrate social regulation of estradiol concentration in female anurans. Elvitegravir concentrations in seminal plasma in HIVinfected men.
Ten men were included. To determine the relationship between resolution of NASH and dyslipidemia. Individuals in the Pioglitazone vs. Change in lipid levels at 96 weeks was compared between those with and without NASH resolution. Dyslipidemia at baseline was frequent, with low high-density lipoprotein HDL 5. Treatment group did not impact lipids. Individuals with resolution of NASH may still be at increased risk of cardiovascular disease. Plasma galanin concentrations in obese, normal weight and anorectic women.
Galanin is believed to play a role in the control of eating behavior. No information is available on its concentrations in the biological fluids in human obesity, and this study aimed to clarify this. We measured plasma galanin and serum insulin levels in 30 obese, 35 normal weight and 11 anorectic women. Mean galanin values were quite similar in obese and control subjects Insulin levels were significantly increased and decreased in obese and anorectic patients, respectively, compared to controls.
In conclusion, plasma galanin concentrations appear to be comparable in obese, normal weight and anorectic subjects. This does not exclude a role of galanin in the regulation of eating behavior since variations of the peptide in discrete brain areas may not be detectable in general circulation and peripheral sources of the peptide may contribute to its plasma levels. Also, our data suggest that galanin does not play a major role in the regulation of insulin secretion in humans. Postprandial plasma D-lactate concentrations after yogurt ingestion. The risk of D-lactic acidosis after consumption of yogurt was investigated in seven healthy volunteers.
After ingestion of yogurt containing 1. That was half the maximum concentration after the equivalent amount of D-lactate in the form of an aqueous solution of DL-lactate. The shape of the postprandial plasma D-lactate peak was flatter, but much broader after yogurt than after the aqueous solution, the peak areas being equal.
Signs of a mild, transient, compensated metabolic acidosis, which was apparent in case of the aqueous lactic acid solution did not occur in case of yogurt. It is concluded that the consumption of foods containing D-lactic acid gives no reason for concern in healthy adults. Genotype-phenotype association was assessed by using multiple linear regression models, assuming an additive model of inheritance. Combination induction plasma tube and current concentrator for introducing a sample into a plasma.
See a Problem?
An induction plasma tube in combination with a current concentrator. The rent concentrator has a substantially cylindrical body having an open end and a partially closed end which defines an aperture. A first slot extends the longitudinal length of the cylindrical body and a second slot extends radially outward from the aperture.
Together the first and second slots form a single L-shaped slot. The current concentrator is disposed within a volume bounded by an induction coil substantially along the axis thereof, and when power is applied to the induction coil a concentrated current is induced within the current concentrator aperture. The concentrator is moveable relative to the coil along the longitudinal axis of the coil to control the amount of current which is concentrated at the aperture. Plasma bupivacaine concentrations following orbital injections in cats. To determine plasma bupivacaine concentrations after retrobulbar or peribulbar injection of bupivacaine in cats.
Randomized, crossover, experimental trial with a 2 week washout period. Six adult healthy cats, aged years, weighing 4. Blood 2 mL was collected before and at 5, 10, 15, 22, 30, 45, 60, , and minutes after bupivacaine injection. Atipamezole was administered approximately 30 minutes after bupivacaine injection. Plasma bupivacaine and 3-hydroxybupivacaine concentrations were determined using liquid chromatography-mass spectrometry. Bupivacaine maximum plasma concentration C max and time to C max T max were determined from the data. The bupivacaine median range C max and T max were 1.
In both treatments the 3-hydroxybupivacaine peak concentration was 0. In healthy cats, at doses up to 2 mg kg -1 , bupivacaine peak plasma concentrations were approximately half that reported to cause arrhythmias or convulsive electroencephalogram EEG activity in cats, and about one-sixth of that required to produce hypotension.
Published by Elsevier Ltd. Plasma visfatin level in lean women with PCOS: The present study was undertaken to investigate the association between plasma visfatin concentrations and inflammatory markers such as interleukin-6 IL-6 and high-sensitive C-reactive protein hsCRP in company with several metabolic parameters in lean women with polycystic ovary syndrome PCOS.
PCOS was defined according to the Rotterdam criteria. Plasma visfatin level in the PCOS group was higher than that in the control group. Plasma visfatin levels were positively associated with total cholesterol, high density lipoprotein, hirsutism score, total testosterone and FAI. Plasma visfatin level was negatively associated with SHBG. In multivariate regression analyses, only FAI and high density lipoprotein-cholesterol HDL-C showed a significant association with serum visfatin. Our data indicates that plasma visfatin levels are associated with HDL-C and markers of hyperandrogenism, but it is not associated with proinflammatory markers and insulin resistance in lean women with PCOS.
Use of antibiotics is associated with lower enterolactone plasma concentration. High enterolactone levels may have health benefits in relation to risk of noncommunicable diseases. Enterolactone is produced by the colonic microbiota after intake of lignans and treatment with antimicrobials may result in altered enterolactone production. This study investigates the association between antibiotic use and enterolactone concentration.
The participants were healthy at enrollment, but were later diagnosed with cancer. At enrollment, participants had blood drawn and completed a food frequency questionnaire and lifestyle questionnaire. Antibiotic use was assessed as reimbursed antibiotic prescriptions up to 12 months before enrollment.