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Bowel anastomoses are common procedures in both elective and emergency general surgery. The anastomotic technique selected depends upon site of anastomosis, bowel calibre and quality and underlying disease process. One important factor in the decision to perform a particular anastomosis, however, remains individual surgical experience and personal preference. The theory behind creating a safe, healthy bowel anastomosis remains constant, irrespective of the technique chosen.

Since the introduction of stapling instruments in the early s one of the main choices open to the gastrointestinal surgeon is whether to create a sutured or stapled anastomosis. This question has been investigated extensively over the past 40 years with mixed results. In this article trials comparing sutured and stapled bowel anastomoses have been reviewed to provide a summary of the available evidence to help the practising general surgeon with this decision.

Anastomosis or anastomoses and bowel or colon or gastrointestinal or GI and sutured or handsewn or stapled.

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The limits were set to English language, human studies and the dates included were - March Abstracts were reviewed and articles comparing anastomotic techniques including both randomised and non-randomised studies were obtained. In total, 42 studies were included in this review. Articles relating to any surgical technique other than the actual anastomosis e.

Thus, the most important factors in the creation of a bowel anastomosis are: The choice of anastomotic technique may be influenced by the diameter of the bowel ends, oedema, accessibility and site of anastomosis, contamination, available time and equipment and underlying pathology. Anastomoses can be described as follows: Stapling has been compared with suturing in various trials since the introduction of stapling devices in the s. Between and several case series and small randomised controlled trials RCTs showed no significant difference in anastomotic leak rates, morbidity or mortality between sutured and stapled anastomoses throughout the gastrointestinal tract[ 8 - 11 ].

This study included elective and emergency anastomoses performed anywhere from the oesophagus to the low rectum, with patients randomised to a sutured or stapled technique intra-operatively. One thousand four patients under the care of 13 general surgeons in five hospitals were included.

Overall clinical leak rate, morbidity and mortality were not significantly different[ 12 ]. It was concluded, following these studies, that both suturing and stapling could be performed safely throughout the gastrointestinal tract[ 8 - 12 ]. More recently, however, numerous studies have investigated the benefits of particular techniques in specific situations, and meta-analyses of RCTs have demonstrated differences not previously detected.

A right hemicolectomy and ileocolic anastomosis is a common procedure in the elective and emergency setting. Case series have suggested that both stapled and sutured anastomoses can be performed with a very low risk of anastomotic leak[ 13 ]. A large RCT was published in regarding elective right hemicolectomy for colonic adenocarcinoma. In the Cochrane Collaboration published a meta-analysis of RCTs regarding ileocolic anastomoses[ 15 ]. Trials comparing stapled side-to-side anastomoses with any suturing technique were included.

This produced patients of whom had stapled and had sutured anastomoses. Stapled anastomoses were associated with significantly fewer anastomotic leaks than hand-sewn anastomoses odds ratio 0. Subgroup analysis revealed the same result in patients operated on for colonic cancer odds ratio 0.

There was no significant difference in other complications, mortality or length of hospital stay[ 15 ]. A stapled side-to-side anastomosis is recommended following a right hemicolectomy, particularly if this operation is performed for a colonic adenocarcinoma[ 15 ]. There are several factors to consider in the surgical management of Crohns disease: In addition to anastomotic healing the risk of Crohns recurrence and the need for re-operation must also be considered. This may also be influenced by anastomotic technique[ 16 - 20 ].

Whilst one randomised study showed anastomotic leak rates to be equivalent in the stapled and sutured groups[ 21 ], several subsequent randomised and non-randomised studies have shown a reduced risk of anastomotic leak[ 16 , 22 ] and a reduced risk of overall complications[ 17 , 19 ] with a stapled anastomosis. A reduced risk of reoperation or a delayed reoperation rate for recurrent Crohns following a stapled anastomosis has also been demonstrated in several studies[ 17 - 19 ].


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A meta-analysis comparing sutured end-to-end anastomoses with other anastomoic configurations following Crohns resection was published in [ 23 ]. Two RCTs and six non-randomised studies were included, giving a total of patients. The leak rate of end-to-end anastomoses was 6. One hundred and seventy-one patients were randomised to a sutured end-to-end or stapled side-to-side anastomosis.

Symptomatic recurrence rates were also similar sutured Long-term follow-up data is awaited with interest. No evidence favours a sutured end-to-end anastomosis. The circular stapled anastomosis in both high and low anterior resections has been extensively studied. Multiple small RCTs and several larger retrospective studies have been published with conflicting results. Some have suggested that the anastomotic leak rates are similar[ 25 - 29 ]; some that stapling is preferable to suturing[ 30 ], and vice versa[ 31 ].

One large RCT reported that while in experienced hands the anastomotic leak rates were equivalent, when performed by a trainee the sutured anastomosis resulted in a higher leak rate[ 32 ]. A further large RCT involving colorectal anastomoses subgroup analysis of a larger trial including all GI tract anastomoses reported a statistically significant increase in the radiological leak rate in the sutured colorectal anastomosis group, a trend towards a reduced clinical leak rate in this group, and no difference in the overall leak rate[ 33 , 34 ].

A meta-analysis of RCTs was published in to clarify these results[ 35 ]. Nine trials were included in which patients were randomised to a sutured or stapled elective colorectal anastomosis. No patient had to be re-operated on for this complication[ 35 ]. The authors concluded that there was no demonstrable superiority of one technique over the other, regardless of the level of the anastomosis.

They advised that the decision regarding whether to perform a stapled or a sutured colorectal anastomosis remains a matter of surgical judgement[ 35 ]. Recent studies regarding the stapled colorectal anastomosis have suggested routine mobilisation of the splenic flexure and a stapled colo-pouch or end-to-side anastomosis. Splenic flexure mobilisation allows the better-perfused descending colon to be anastomosed to the rectum and the use of an end-to-side anastomosis or a colo-pouch tends to fill the pelvis, reducing dead space in which a haematoma or collection could develop[ 5 ].

In , a retrospective study of 84 trauma patients, who underwent gastrointestinal anastomoses in a single United States trauma centre over a four-year period was published[ 36 ].

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This included small bowel and 17 large bowel anastomoses, of which 58 were stapled and 60 hand-sewn. Another retrospective study countered this[ 37 ], showing that of small bowel anastomoses stapled; 34 sutured there was no significant difference in anastomotic leak rate or other intra-abdominal complication. It did, however, show that enterotomies which did not require resection were best treated by sutured repair[ 37 ]. In a multi-centre retrospective study which included patients from the study compared the incidence of complications following emergency bowel resection and anastomosis in trauma[ 38 ].

Data over a four-year period from five US Level 1 trauma centres was included, producing a total of patients with anastomoses stapled; sutured. The injury severity score and the distribution of small bowel and large bowel anastomoses in the two groups were not significantly different. A recent study compared stapled with sutured colonic anastomoses following penetrating trauma[ 39 ].

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This was a prospective, multi-centre non-randomised study including patients. They found no significant difference in anastomotic leak rate or other abdominal complications between the two groups, concluding that sutured and stapled colonic anastomoses are equally valid. These results should be interpreted with caution, however, as the stapled and sutured groups were not well matched: The problem with all of these studies is that they are not randomised, so results are subject to bias[ 36 - 39 ].

However this currently remains our best available evidence, and suggests that stapled small bowel anastomoses may be best avoided in trauma[ 36 , 38 ]. The question of the stapled colonic anastomosis remains uncertain. Several studies have compared methods of small bowel anastomosis in elective reversal of loop ileostomy. Randomised and non-randomised studies have not previously shown any significant difference in anastomotic leak rate[ 40 - 43 ], however the rate of post-operative bowel obstruction can be affected by anastomotic technique[ 44 , 45 ].

Mobilising the ileostomy spout and closing the enterotomy, rather than resecting the spout and performing an anastomosis can reduce the risk of small bowel obstruction[ 44 ], as can performing a stapled side-to-side anastomosis rather than a sutured end-to-end anastomosis[ 45 ]. A meta-analysis of six previous studies two RCTs and four non-randomised studies including participants was published in [ 46 ].

This showed no statistically significant difference in complications between stapled and sutured anastomoses. There was, however, a non-significant trend favouring stapled anastomoses with regard to lower small bowel obstruction rates, anastomotic leaks and shorter operating times[ 46 ]. Following mobilisation of a loop ileostomy either excision of the spout and a stapled side-to-side anastomosis or mobilisation of the spout and sutured closure of the enterotomy are reasonable options[ 6 , 44 - 46 ].

Resection and sutured anastomosis is not the preferred technique, although the evidence for this is mainly from retrospective, non-randomised studies[ 6 , 44 - 46 ].

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The theory behind a good bowel anastomosis remains consistent, whether a stapled or sutured technique is employed: Either stapled or sutured techniques are suitable in most situations. In recent years, however, evidence has shown particular anastomotic techniques to be advantageous in specific settings - in this article the available literature is reviewed to provide the on-call general surgeon with the information required to make an evidence-based decision regarding anastomotic technique.

In the case of ileocolic anastomoses following a right hemicolectomy for cancer, level 1a evidence recommends the use of a stapled side-to-side technique. In contrast, level 1a evidence has shown that sutured or endoluminal circular stapled techniques are equally suitable for colorectal anastomoses. There is level 1b evidence suggesting that a stapled side-to-side anastomosis may be advantageous in a Crohns ileocaecal resection, although there is some conflicting data as discussed.

In trauma patients level 3 evidence suggests that following a small bowel resection a sutured anastomosis will result in significantly fewer leaks and intra-abdominal abscesses than a stapled technique. A Clinician's Guide to Quality Improvement. Transition and Change in Collectivist Family Life: Strategies for Clinical Practice with Asian Americans. Access Medicine Create personal account to access. Crohn's Disease and Ulcerative Colitis: The Role of Pendrin in Health and Disease: Ebsco access limited to a single user. Manual of Healthcare Leadership: Essential Strategies for Physician and Administrative Leaders, Performance Improvement for Healthcare: Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics: McGraw-Hill This title may take up to 5 minutes to load.

From an Association to a Royal College: Management Lessons from Mayo Clinic: The Cleveland Clinic Way: Ref access limited to seven simultaneous users. Advances in Patient Safety: From Research to Implementation, Vol. New Directions and Alternative Approaches, Vol. Adaption of Microbial Life to Environmental Extremes: Novel Research Results and Application, 2nd ed.

Atlas of Endoscopic Neurosurgery of the Third Ventricle: Ebrary access limited to a single user.

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Inflammatory Disorders of the Nervous System: Pathogenesis, Immunology, and Clinical Management, 2nd ed. Neuropathology of Huntington's Disease: The Hippocampus from Cells to Systems: Ebsco access limited to six simultaneous users. Brain Metastases from Primary Tumors, Volume 3:


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